Chemotaxis as a Mechanism for Recruitment of Mucosal Plasma Cell Precursors
Precursor cells in mucosal-associated lymphoid tissue travel via the lymphatic system to the regional lymph nodes, proceed to the blood and then preferentially home to a number of sites, including the gut, respiratory tract, and during lactation, the mammary glands where they complete their differentiation into IgA plasma cells (1–6). The basis of the selective homing of these cells to secondary sites is not understood. The objective of the current work is to begin to examine Chemotaxis as a possible mechanism.
KeywordsChemotactic Factor Boyden Chamber Peripheral Node Lower Compartment Migration Index
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