Chemotaxis as a Mechanism for Recruitment of Mucosal Plasma Cell Precursors

  • S. J. Czinn
  • J. Robinson
  • M. E. Lamm
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)


Precursor cells in mucosal-associated lymphoid tissue travel via the lymphatic system to the regional lymph nodes, proceed to the blood and then preferentially home to a number of sites, including the gut, respiratory tract, and during lactation, the mammary glands where they complete their differentiation into IgA plasma cells (1–6). The basis of the selective homing of these cells to secondary sites is not understood. The objective of the current work is to begin to examine Chemotaxis as a possible mechanism.


Chemotactic Factor Boyden Chamber Peripheral Node Lower Compartment Migration Index 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Lamm, M.E., Adv. Immunol. 22, 223, 1976.PubMedCrossRefGoogle Scholar
  2. 2.
    Guy-Grand, D., Griscelli, C., Vassalli, P., Eur. J. Immunol. 4, 435, 1974.PubMedCrossRefGoogle Scholar
  3. 3.
    McWilliams, M., Phillips-Quagliata, J.M., Lamm, M.E., J. Immunol. 115, 54, 1975.PubMedGoogle Scholar
  4. 4.
    McDermott, M.R., Bienenstock, J., J. Immunol. 122, 1892, 1979.PubMedGoogle Scholar
  5. 5.
    Montgomery, P.C., Ayyildiz, A., Lemaitre-Coelho, I.M. and Vaerman, J.-P., Ann. N.Y. Acad. Sci. 409, 428, 1983.PubMedCrossRefGoogle Scholar
  6. 6.
    Roux, M.E., McWilliams, M., Phillips-Quagliata, J.M., Weisz-Carrington, P. and Lamm, M.E., J. Exp. Med. 146, 1311, 1977.PubMedCrossRefGoogle Scholar
  7. 7.
    Parrott, D.M.V., Ferguson, A., Immunology 26, 571, 1974.PubMedGoogle Scholar
  8. 8.
    Hall, J.G., Hopkins, J., Orlans, E., Eur. J. Immunol. 7, 30, 1977.PubMedCrossRefGoogle Scholar
  9. 9.
    Stevens, S.K., Weissman, I.L. and Butcher, E.C., J. Immunol. 128, 844, 1982.PubMedGoogle Scholar
  10. 10.
    Ottaway, C.A., Bruce, R.G. and Parrott, D.M.V., Immunology 49, 641, 1983.PubMedGoogle Scholar
  11. 11.
    Larson, B.L., J. Dairy Res. 46, 161, 1979.PubMedCrossRefGoogle Scholar
  12. 12.
    Wysocki, L.J. and Sato, V.L., Proc. Natl. Acad. Sci. USA 75, 2844, 1978.PubMedCrossRefGoogle Scholar
  13. 13.
    El-Naggar, A.K., Van Epps, D.E. and Williams, R.C., Cell. Immunol. 60, 43, 1981.PubMedCrossRefGoogle Scholar
  14. 14.
    Ward, P.A., Unanue, E.R., Goralnick, S.J. and Shreiner, G.F., J. Immunol. 119, 416, 1977.PubMedGoogle Scholar
  15. 15.
    Wilkinson, P.C., Parrott, D.M., Russell, R.J. and Sless, F., J. Exp. Med. 145, 1158, 1977.PubMedCrossRefGoogle Scholar
  16. 16.
    Zigmond, S.H. and Hirsch, J.G., J. Exp. Med. 137, 387, 1973.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • S. J. Czinn
    • 1
  • J. Robinson
    • 1
  • M. E. Lamm
    • 1
  1. 1.Institute of Pathology and Department of PediatricsCase Western Reserve UniversityClevelandUSA

Personalised recommendations