Migration of Peyer’s Patch Iga Precursor Cells
It is generally accepted that Peyer’s patches (PP) are an enriched source of precursor cells for the IgA plasma cells in the gut lamina propria (GLP) (1,2). The IgA precursor cells migrate to the mesenteric lymph nodes (MLN), enter the blood circulation via the thoracic duct, and eventually arrive in the GLP where they become resident plasma cells (3–5). In an attempt to understand this migration journey more clearly, we studied the migration, lodging and differentiation properties of the IgA precursor cells by transferring lymphoid cells between syngeneic and Ig allotype congenic mice and examining the Ig isotype expression potential for the lymphoid cells of the gut-associated lymphoid tissue (GALT). The results led to a migration outline highlighted with asynchronized differentiations. The results are briefly reviewed in this paper.
KeywordsLymphoid Cell Mesenteric Lymph Node Thoracic Duct Enrich Source Walter Reed Army Institute
Unable to display preview. Download preview PDF.