Rabbit IgA Heavy Chain Genes: Cloning and In Vitro Expression

  • R. C. Burnett
  • R. D. Schneiderman
  • K. L. Knight
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)


Southern blot analysis of rabbit germline DNA showed the rabbit genome contained at least 10 Ca genes (1). This observation was of particular interest since both mouse and human have only one and two Ca genes, respectively. Genomic blot data are consistent with studies of rabbit IgA heavy chain allotypes which suggested the existence of multiple IgA isotypes (2–4), To further examine the complexity and genetic control of rabbit IgA, we have undertaken molecular and genetic studies of the IgA heavy chains.


Heavy Chain Southern Blot Analysis Secretory Component Lambda Light Chain Domestic Rabbit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Knight, K.L., Burnett, R.C. and McNicholas, J.M., J. Immunol. 134, 1245, 1985.PubMedGoogle Scholar
  2. 2.
    Conway, T.P., Dray, S. and Lichter, E.A., J. Immunol. 102, 544, 1969.PubMedGoogle Scholar
  3. 3.
    Conway, T.P., Dray, S. and Lichter, E.A., J. Immunol. 103, 622, 1969.Google Scholar
  4. 4.
    Muth, K.L., Hanly, W.C. and Knight, K.L., Molec. Immun. 20, 989, 1983.PubMedCrossRefGoogle Scholar
  5. 5.
    Knight, K.L., Martens, C.L., Stoklosa, CM. and Schneiderman, R.D., Nucl. Acid Res. 12, 1657, 1984.CrossRefGoogle Scholar
  6. 6.
    Oi, V.T., Morrison, S.L., Herzenberg, L.A. and Berg, P., Proc. Natl. Acad. Sci. USA 80, 825, 1983.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • R. C. Burnett
    • 1
  • R. D. Schneiderman
    • 1
  • K. L. Knight
    • 1
  1. 1.Department of Microbiology and ImmunologyUniversity of Illinois College of Medicine at ChicagoChicagoUSA

Personalised recommendations