Mucosal T Lymphocytes in Human Colonic Schistosomiasis: Relationship to MHC Antigens
Immunity to schistosomal infections has attracted considerable attention due to its endemic prevalence in the Third World, although much of the data available derives from animal models. Human studies have concentrated on systemic immunity, where it has long been known that chronic helminthic infections result in major perturbations (1). Mechanism of immunity in schistosomiasis are not fully understood, although recently it has been reported that circulatory T lymphocyte CD4:CD8 ratios are perturbed (2), and parasite-derived immunosuppressive factor(s) have been described (3), which may occur at both local and systemic levels.
KeywordsIrritable Bowel Syndrome Lamina Propria Granuloma Formation Colonic Epithelium Schistosomal Infection
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