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Mucosal T Lymphocytes in Human Colonic Schistosomiasis: Relationship to MHC Antigens

  • S. Badr-el-Din
  • L. K. Trejdosiewicz
  • D. J. Oakes
  • R. V. Heatley
  • A. Abou-Khadr
  • G. Janossy
  • M. S. Losowsky
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)

Abstract

Immunity to schistosomal infections has attracted considerable attention due to its endemic prevalence in the Third World, although much of the data available derives from animal models. Human studies have concentrated on systemic immunity, where it has long been known that chronic helminthic infections result in major perturbations (1). Mechanism of immunity in schistosomiasis are not fully understood, although recently it has been reported that circulatory T lymphocyte CD4:CD8 ratios are perturbed (2), and parasite-derived immunosuppressive factor(s) have been described (3), which may occur at both local and systemic levels.

Keywords

Irritable Bowel Syndrome Lamina Propria Granuloma Formation Colonic Epithelium Schistosomal Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • S. Badr-el-Din
    • 1
  • L. K. Trejdosiewicz
    • 1
  • D. J. Oakes
    • 1
  • R. V. Heatley
    • 1
  • A. Abou-Khadr
    • 2
  • G. Janossy
    • 3
  • M. S. Losowsky
    • 1
  1. 1.Department of Medicine, St. James’s University HospitalUniversity of LeedsLeedsUK
  2. 2.Alexandria UniversityAlexandriaEgypt
  3. 3.Academic Department of ImmunologyRoyal Free HospitalLondonUK

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