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Differential Tissue Distribution of HLA-DR, -DP and -DQ Antigens

  • U. Forsum
  • K. Claesson
  • R. Jonsson
  • A. Karlsson-Parra
  • L. Klareskog
  • A. Scheynius
  • U. Tjernlund
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)

Abstract

At least three chromosomal loci code for class II transplantation antigens in humans; HLA-DR, -DP and -DQ. These antigens have been implicated to be critical restriction elements in various immune reactions. It is, however, far from clear how and where the class II antigens perform their functions. Available in vivo and in vitro data suggest that class II antigens are constitive cell membrane components on certain types of cells such as dendritic cells of the spleen and the Langerhans cell of the epidermis (1,2). Furthermore, class II antigens can be induced by gamma interferon and other stimuli on a variety of epithelial and endothelial cells that do not always express these antigens (3).

Keywords

Primary Biliary Cirrhosis Lichen Planus Mycosis Fungoides Local Immune Reaction Anti Class 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • U. Forsum
    • 1
    • 2
    • 3
  • K. Claesson
    • 1
    • 2
    • 3
  • R. Jonsson
    • 1
    • 2
    • 3
  • A. Karlsson-Parra
    • 1
    • 2
    • 3
  • L. Klareskog
    • 1
    • 2
    • 3
  • A. Scheynius
    • 1
    • 2
    • 3
  • U. Tjernlund
    • 1
    • 2
    • 3
  1. 1.Department of Clinical BacteriologyKarolinska InstituteStockholmSweden
  2. 2.Department of Oral PathologyUniversity of GöteborgSweden
  3. 3.Institute of Clinical Bacteriology and Departments of Medical and Physiological Chemistry, Urology and DermatologyUniversity of UppsalaSweden

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