Syngeneic and Allogeneic T Cell Reactivity to I-Region Determinants on Rat Intestinal Epithelial Cells

  • P. W. Bland
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)


Class II (la) molecules of the major histocompatibility complex (MHC) are integral membrane glycoproteins found, in normal circumstances, on cells of various lineages throughout the body. Their expression may be induced on other cell types however, by inflammatory mediators, for example, γ interferon (1). They function in the immune response to restrict the presentation of protein antigens to immunoregulatory T cells (2). They also act as auto- and allo-antigens in mixed lymphocyte responses (3).


Major Histocompatibility Complex Integral Membrane Glycoprotein Monoclonal Antiserum Nylon Wool Column Mixed Lymphocyte Response 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • P. W. Bland
    • 1
  1. 1.Department of Veterinary MedicineUniversity of BristolLangford, BristolUK

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