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Antigen Presentation by Gut Epithelial Cells: Secretion by Rat Enterocytes of a Factor with IL-1-Like Activity

  • P. W. Bland
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)

Abstract

Evidence is emerging that the epithelial interface of the gut may play an important role in directing the type of immune response initiated towards enteric antigens. Soluble protein antigens are processed to constituent antigenic peptides during absorption from the lumen (1) and such processing may give rise to circulating fragments with greater tolerogenicity than the native protein (2). In addition to its antigen processing function, the epithelium may be directly involved in the presentation of absorbed antigen, and the local induction of immunoregulatory lymphocytes. Thus, fully differentiated absorptive epithelial cells (EC) isolated from the rat small intestine can present soluble protein antigens to immune lymph node T cells in vivo (3), causing them to proliferate and differentiate into antigen-specific suppressor cells (4).

Keywords

Muramyl Dipeptide Induction Culture Drain Lymph Node Cell Nylon Wool Column Absorptive Epithelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Stem, M. and Walker, W.A., Am. J. Physiol. 246, G556, 1984.Google Scholar
  2. 2.
    Bruce, M.G. and Ferguson, A., Immunology 57, 627, 1986.PubMedGoogle Scholar
  3. 3.
    Bland, P.W. and Warren, L.G., Immunology 58, 1, 1986.PubMedGoogle Scholar
  4. 4.
    Bland, P.W. and Warren, L.G., Immunology 58, 9, 1986.PubMedGoogle Scholar
  5. 5.
    Ziegler, K. and Unanue, E., J. Immunol. 127, 1869, 1981.PubMedGoogle Scholar
  6. 6.
    Lee, K.C., Wilkinson, A. and Wong, M., Cell. Immunol. 48, 79, 1979.PubMedCrossRefGoogle Scholar
  7. 7.
    Kaye, J., Gillis, S., Mizel, S.B., Shevach, E.M., Males, T.R., Dinarello, C.A., Lachman, L.B. and Janeway, C.A., J. Immunol. 133, 1339, 1984.PubMedGoogle Scholar
  8. 8.
    Luger, T.A., Stadler, B.M., Katz, S.I. and Oppenheim, J.J., J. Immunol. 127, 1493, 1981.PubMedGoogle Scholar
  9. 9.
    Fontana, A., Kristensen, F., Dubs, R., Gemsa, D. and Weber, E., J. Immunol. 129, 2413, 1982.PubMedGoogle Scholar
  10. 10.
    Lovett, D.H., Ryan, J.L. and Sterzel, R.B., J. Immunol. 130, 1796, 1983.PubMedGoogle Scholar
  11. 11.
    Roska, A.K., Johnson, A.R. and Lipsky, P.E., J. Immunol. 132, 136, 1984.PubMedGoogle Scholar
  12. 12.
    Matsushima, K., Procopio, A., Abe, H., Scala, G., Ortaldo, J.R. and Oppenheim, J.J., J. Immunol. 135, 1132, 1985.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • P. W. Bland
    • 1
  1. 1.Department of Veterinary MedicineUniversity of BristolLangford, BristolUK

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