The Role of Epithelial Cells as Accessory Cells
Mucosal immunity is characterized by poor or absent responses to most orally administered antigens (1,2). Antigens access into gut-associated lymphoid tissues (GALT) is partially inhibited by a mucous coat containing glycoproteins and secretory IgA (3). Those antigens which do gain access to GALT are thought to enter through specialized epithelial cells overlying Peyer’s patches, the so-called M cell (M). Although it has been suggested that these cells bear receptors for a number of bacterial and viral antigens (4), the relative numbers of these cells are small and therefore antigen processing via such a mechanism may not be very efficient.
KeywordsAdherent Cell Tetanus Toxoid Accessory Cell Mucosal Immune Response Mixed Lymphocyte Culture
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