The Role of Epithelial Cells as Accessory Cells

  • L. Mayer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)


Mucosal immunity is characterized by poor or absent responses to most orally administered antigens (1,2). Antigens access into gut-associated lymphoid tissues (GALT) is partially inhibited by a mucous coat containing glycoproteins and secretory IgA (3). Those antigens which do gain access to GALT are thought to enter through specialized epithelial cells overlying Peyer’s patches, the so-called M cell (M). Although it has been suggested that these cells bear receptors for a number of bacterial and viral antigens (4), the relative numbers of these cells are small and therefore antigen processing via such a mechanism may not be very efficient.


Adherent Cell Tetanus Toxoid Accessory Cell Mucosal Immune Response Mixed Lymphocyte Culture 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • L. Mayer
    • 1
  1. 1.Division of Clinical ImmunologyThe Mount Sinai School of Medicine of the University of New YorkNew YorkUSA

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