A Novel Pre-B Cell Precursor: Phenotypic Characterization and Differentiation Induction by Dendritic Cell-T Cell Mixtures
Recently, culture systems have been developed which support the growth of multipotential stem cells (1), pro-B cells (2), pre-B cells (3) or mixtures of several early stages (4,5), and these have begun to improve our understanding of very early stages of B lymphocyte differentiation. In some of these systems, differentiation to a subsequent developmental stage can be induced, but multiple levels of differentiation have not been observed under conditions suitable for detailed analysis of phenotypic and genotypic events during these maturation processes.
KeywordsCytoplasmic Staining Cell Stage Multipotential Stem Cell Cytocentrifuge Preparation Subsequent Developmental Stage
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