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Isolation of Peyer’s Patch T Cell Subsets Involved in Isotype Specific Immunoregulation

  • K. W. Beagley
  • H. Kiyono
  • C. D. Alley
  • J. H. Eldridge
  • J. R. McGhee
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)

Abstract

Antigenic stimulation of the gut-associated lymphoreticular tissue (GALT) in the mouse results in an immune response at mucosal sites distant from the gut which is dominated by antibody of the IgA isotype. The morphology of murine Peyer’s patch and the composition of the resident lymphoid and accessory cells is now well established. T and B lymphocytes are found in distinct zones beneath a specialized epithelial tissue. The B cell areas contain numerous IgA precursor B cells and within the T cell zone all T cell subsets are present (Lyt 1+/L3T4+, Lyt 2+ and T contra-suppressor cells). Contrary to earlier reports, Peyer’s patch cells prepared by enzymatic digestion also contain accessory cells, e.g., both macrophages and dendritic cells.

Keywords

Accessory Cell Specialized Epithelial Tissue Bone Marrow Mononuclear Cell Cluster Population Sodium Periodate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • K. W. Beagley
    • 1
  • H. Kiyono
    • 2
  • C. D. Alley
    • 3
  • J. H. Eldridge
    • 1
  • J. R. McGhee
    • 1
  1. 1.Departments of of MicrobiologyUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.Oral BiologyUniversity of Alabama at BirminghamBirminghamUSA
  3. 3.Cell Biology and AnatomyUniversity of Alabama at BirminghamBirminghamUSA

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