Advertisement

Perturbations in Peyer’s Patch B Cell Populations Indicative of Priming for a Secretory IgA Response

  • J. J. Cebra
  • P. M. Griffin
  • D. A. Lebman
  • S. D. London
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)

Abstract

Many years after Johann Peyer described localized accumulations of lymphoid cells in the mammalian intestinal mucosa (Peyer’s patches, PP) (1) we proposed a special role for them in the development of secretory IgA responses (2). Initially we found that rabbit PP cells were enriched sources of precursors for IgA-plasma cells and could repopulate the spleen and intestinal lamina propria of irradiated recipients with such plasma cells much more effectively than could lymphoid cells from other sources (2). This was a somewhat accidental finding made while trying to elucidate the mechanism for transporting IgA from lamina propria plasma cells into the gut lumen. Jose O’Daly had been following up the detection of secretory component (SC) in glandular epithelial cells (3) and observed that many of the apparently nonspecialized epithelial cells lining the Lieberkühn crypts contained numerous cytoplasmic granules that stained positively for both IgA and SC (4). The issue became the direction of flow — were the granules the result of endocytosis of sIgA from the intestinal fluid in the crypt lumen or were they formed at the plasma membrane on the basal side of the cells from IgA dimer secreted by the proximal plasma cells?

Keywords

Lamina Propria Germinal Center Cholera Toxin Alpha Chain Secretory Component 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Gillespie, C.G. (Ed.), Dir. of Sci. Biography, 10, 567, 1974.Google Scholar
  2. 2.
    Craig, S.W. and Cebra, J.J., J. Exp. Med. 134, 188, 1971.PubMedCrossRefGoogle Scholar
  3. 3.
    Tomasi, T.B., Jr., Tan, E.M., Solomon, A. and Prendergast, R.A., J. Exp. Med. 121, 101, 1965.PubMedCrossRefGoogle Scholar
  4. 4.
    O’Daly, J.A., Craig, S.W. and Cebra, J.J., J. Immunol. 106, 286, 1971.PubMedGoogle Scholar
  5. 5.
    Frensdorff, A., Jones, P.P., Berwald-Netter, Y., Cebra, J.J. and Mage, R., Science 171, 391, 1971.PubMedCrossRefGoogle Scholar
  6. 6.
    Jones, P.P., Craig, S.W., Cebra, J.J. and Herzenberg, L.A., J. Exp. Med. 140, 452, 1974.PubMedCrossRefGoogle Scholar
  7. 7.
    Klinman, N.R., J. Exp. Med. 136, 241, 1972.PubMedCrossRefGoogle Scholar
  8. 8.
    Gearhart, P.J. and Cebra, J.J., J. Exp. Med. 149, 216, 1979.PubMedCrossRefGoogle Scholar
  9. 9.
    Nossal, G.J.V. and Pike, B.L., J. Immunol. 120, 145, 1978.PubMedGoogle Scholar
  10. 10.
    Cebra, J.J., Cebra, E.R., Kotloff, D.B., Lebman, D.A., Schweitzer, P.A. and Shahin, R.D., Biochem. Soc. Symp. 51, 159, 1986.PubMedGoogle Scholar
  11. 11.
    Hurwitz, J.L., Tagart, V.B., Schweitzer, P.A. and Cebra, J.J., Eur. J. Immunol. 12, 342, 1982.PubMedCrossRefGoogle Scholar
  12. 12.
    Cebra, J.J., Gearhart, P.J., Kamat, R., Robertson, S.M. and Tseng, J., Cold Spring Harbor Symp. Quant. Biol. 41, 201, 1977.PubMedCrossRefGoogle Scholar
  13. 13.
    Cebra, J.J., Fuhrman, J.A., Gearhart, P.J., Hurwitz, J.L. and Shahin, R.D., in Recent Advances in Mucosal Immunity, (Edited by Strober, W., Hanson, L.A. and Sell, K.W.), p. 155, Raven Press, New York, 1982.Google Scholar
  14. 14.
    Sigal, N.H., Pickard, A.R., Metcalf, E.S., Gearhart, P.J. and Klinman, N.R., J. Exp. Med. 146, 933, 1977.PubMedCrossRefGoogle Scholar
  15. 15.
    Shahin, R.D. and Cebra, J.J., Infect. Immunity 32, 211, 1981.Google Scholar
  16. 16.
    Cebra, J.J., Gearhart, P.J., Halsey, J.F., Hurwitz, J.L. and Shahin, R.D., J. Reticuloendothelial Soc. 28: (suppl), 61, 1980.Google Scholar
  17. 17.
    Fuhrman, J.A. and Cebra, J.J., J. Exp. Med. 153, 534, 1981.PubMedCrossRefGoogle Scholar
  18. 18.
    Cebra, J.J., Fuhrman, J.A., Lebman, D.A. and London, S.D., in Vaccines 86, (Edited by Brown, F., Chanock, R.M. and Lerner, R.A.), p. 129, Cold Spring Harbor Laboratory, Cold Spring Harbor, 1986.Google Scholar
  19. 19.
    Coico, R.F., Bhogal, B.S. and Thorbecke, G.J., J. Immunol. 131, 2254, 1983.PubMedGoogle Scholar
  20. 20.
    Butcher, E.C., Rouse, R.V., Coffman, R.L., Nottenburg, C.N., Hardy, R.R. and Weissman, I.L., J. Immunol. 129, 2698, 1982.PubMedGoogle Scholar
  21. 21.
    Kraal, G., Weissman, I.L. and Butcher, E.C., Nature 298, 377, 1982.PubMedCrossRefGoogle Scholar
  22. 22.
    Word, C.J., Mushinski, J.F. and Tucker, P.W., EMBO J. 2, 887, 1983.PubMedGoogle Scholar
  23. 23.
    Cebra, J.J., Fuhrman, J.A., Griffin, P., Rose, F.V., Schweitzer, P.A. and Zimmerman, D., Annals of Allergy 53, 541, 1984.PubMedGoogle Scholar
  24. 24.
    Woloschak, G.E., Molec. Immunochem. 23, 581, 1986.CrossRefGoogle Scholar
  25. 25.
    Husband, A.J., Monie, H.J. and Gowans, J.L., in Immunology of the Gut, Ciba Foundation Symposium 46, Elsevier, New York, p. 29, 1977.Google Scholar
  26. 26.
    Pierce, N.F. and Gowans, J.L., J. Exp. Med. 142, 1550, 1975.PubMedCrossRefGoogle Scholar
  27. 27.
    Husband, A.J., J. Immunol. 128, 1355, 1982.PubMedGoogle Scholar
  28. 28.
    Kiyono, H., McGhee, J.R., Mosteller, L.M., Eldridge, J.H., Koopman, W.J., Kearney, J.F. and Michalek, S.M., J. Exp. Med. 156, 1115, 1982.PubMedCrossRefGoogle Scholar
  29. 29.
    Kiyono, H., Cooper, M.D., Kearney, J.F., Mosteller, L.M., Michalek, S.M., Koopman, W.J. and McGhee, J.R., J. Exp. Med. 159, 798, 1984.PubMedCrossRefGoogle Scholar
  30. 30.
    Kiyono, H., Mosteller-Barnum, L.M., Pitts, A.M., Williamson, S.I., Michalek, S.M. and McGhee, J.R., J. Exp. Med. 161, 731, 1985.PubMedCrossRefGoogle Scholar
  31. 31.
    Coffman, R.L., Bond, M.W., Carty, J. and Mosmann, T.R., Progress in Immunology 6, Abs. 3.13.16, p. 267, 1986.Google Scholar
  32. 32.
    Gearhart, P.J., Hurwitz, J.L. and Cebra, J.J., Proc. Natl. Acad. Sci. USA 77, 5424, 1980.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • J. J. Cebra
    • 1
  • P. M. Griffin
    • 1
  • D. A. Lebman
    • 1
  • S. D. London
    • 1
  1. 1.Department of BiologyUniversity of PennsylvaniaPhiladelphiaUSA

Personalised recommendations