T Dependent Induction of an IgA and IgM Anti-Polysaccharide Response

  • M. F. Kagnoff
  • P. D. Murray
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)


The intestinal mucosa is the first site of interaction between the immune system and many foreign antigens and pathogens (1). Major interactions with polysaccharide antigens take place in the gut, and immune responses to bacterial polysaccharides are important in host defenses at mucosal surfaces. Morbidity and mortality from infections with encapsulated bacteria is high in neonates and the elderly. Information regarding how anti-polysaccharide immunity is regulated at mucosal surfaces and changes in that regulation during aging could be of substantial value for strategies to alter anti-polysaccharide immunity and for the design of immunization programs.


Spleen Cell Young Mouse Leuconostoc Mesenteroides Titrate Concentration Polysaccharide Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • M. F. Kagnoff
    • 1
  • P. D. Murray
    • 1
  1. 1.Laboratory of Mucosal Immunology Department of Medicine, M-023-DUniversity of California San DiegoLa JollaUSA

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