Isotype-Specific Immunoregulation: T Contrasuppressor Cells Protect IgA Responses in Oral Tolerance
Murine Peyer’s patches (PP) are enriched in T cell subsets with helper amplifier and contrasuppressor (Tcs) activity (1), and the Tcs cells may play a role in allowing IgA response induction in the presence of T suppressor (Ts) cells which mediate systemic unresponsiveness (1). Continuous oral exposure to thymus-dependent (TD) antigen results in two seemingly-opposite responses, the induction of IgA responses at mucosal sites and systemic unresponsiveness, termed oral tolerance (2,3). C3H/HeJ mice, which are genetically resistant to oral tolerance induction with sheep erythrocytes (SRBC), possess a splenic Tcs cell subset which abolishes oral tolerance when adoptively transferred to syngeneic, C3H/HeN mice. In this study, we summarize recent studies which show that C3H/HeJ PP contain abundant Tcs cell activity which may account for their lack of oral tolerance, and the existence of a Tcs cell subset which preferentially enhances Th cell-mediated IgA responses.
KeywordsAdoptive Transfer Oral Tolerance Sheep Erythrocyte Oral Tolerance Induction Alberta Heritage Foundation
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