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Isotype-Specific Immunoregulation: T Contrasuppressor Cells Protect IgA Responses in Oral Tolerance

  • K. Kitamura
  • I. Suzuki
  • H. Kiyono
  • T. Kurita
  • A. K. Berry
  • D. R. Green
  • J. R. McGhee
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)

Abstract

Murine Peyer’s patches (PP) are enriched in T cell subsets with helper amplifier and contrasuppressor (Tcs) activity (1), and the Tcs cells may play a role in allowing IgA response induction in the presence of T suppressor (Ts) cells which mediate systemic unresponsiveness (1). Continuous oral exposure to thymus-dependent (TD) antigen results in two seemingly-opposite responses, the induction of IgA responses at mucosal sites and systemic unresponsiveness, termed oral tolerance (2,3). C3H/HeJ mice, which are genetically resistant to oral tolerance induction with sheep erythrocytes (SRBC), possess a splenic Tcs cell subset which abolishes oral tolerance when adoptively transferred to syngeneic, C3H/HeN mice. In this study, we summarize recent studies which show that C3H/HeJ PP contain abundant Tcs cell activity which may account for their lack of oral tolerance, and the existence of a Tcs cell subset which preferentially enhances Th cell-mediated IgA responses.

Keywords

Adoptive Transfer Oral Tolerance Sheep Erythrocyte Oral Tolerance Induction Alberta Heritage Foundation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • K. Kitamura
    • 1
  • I. Suzuki
    • 1
  • H. Kiyono
    • 2
  • T. Kurita
    • 1
  • A. K. Berry
    • 1
  • D. R. Green
    • 3
  • J. R. McGhee
    • 1
  1. 1.Departments of Microbiology, The Institute of Dental Research, University StationUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.Oral Biology and Preventive Dentistry, The Institute of Dental Research, University StationUniversity of Alabama at BirminghamBirminghamUSA
  3. 3.Department of Immunology, Faculty of MedicineUniversity of AlbertaEdmontonCanada

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