Antigen-Specific Helper T Cells in the Intestine: Origin and Migration
IgA responses are dependent on T cell cooperation (1–3) and populations of T cells which provide IgA specific help (Thα cells) have been identified in humans (4,5) and mouse (6) and have been cloned from murine Peyer’s patches (PP) (7,8). The migration and distribution of these effector cells is crucial to a successful local response to antigen. Most studies of T cell migration have been undertaken with bulk populations responding to a wide range of antigens with varying tissue distributions but results from these experiments can only reflect the sum of potential influences exerted by a large number of different factors. Some studies have used cloned T cells but the fact that some cloned cells lose surface receptors and display abberrant migratory behaviour (9) is a concern with these models.
KeywordsSpleen Cell Helper Cell Thoracic Duct Keyhole Limpet Hemocyanin Peripheral Lymph Node
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