T Cell Clones that Help IgA Responses

  • J. M. Phillips-Quagliata
  • A. A. Maghazachi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)


I The predominance of IgA in mucosal secretions contrasting with that I of IgG in serum, is commonly thought to reflect the unique life history I of lamina propria IgA plasma cell precursors in the mucosa-associated lymphoid tissue (MALT), especially the gut-associated lymphoid tissue (GALT). I GALT lymphoid nodules seem to provide a milieu in which commitment of B I cells to IgA production is especially favored. While many aspects of this I milieu could theoretically contribute to promoting IgA at the expense of I other isotypes, one of the more attractive hypotheses is that GALT lymphoid I nodules contain higher numbers, relative to other lymphoid organs, of T I cells capable of producing factors necessary for switching, proliferation, I or differentiation of IgA B cells.


Cell Clone Mesenteric Lymph Node Keyhole Limpet Hemocyanin Peripheral Lymph Node Cognate Interaction 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • J. M. Phillips-Quagliata
    • 1
  • A. A. Maghazachi
    • 1
  1. 1.Department of Pathology and Kaplan Cancer CenterNew York University Medical CenterNew YorkUSA

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