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T Cell Clones that Help IgA Responses

  • J. M. Phillips-Quagliata
  • A. A. Maghazachi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)

Abstract

I The predominance of IgA in mucosal secretions contrasting with that I of IgG in serum, is commonly thought to reflect the unique life history I of lamina propria IgA plasma cell precursors in the mucosa-associated lymphoid tissue (MALT), especially the gut-associated lymphoid tissue (GALT). I GALT lymphoid nodules seem to provide a milieu in which commitment of B I cells to IgA production is especially favored. While many aspects of this I milieu could theoretically contribute to promoting IgA at the expense of I other isotypes, one of the more attractive hypotheses is that GALT lymphoid I nodules contain higher numbers, relative to other lymphoid organs, of T I cells capable of producing factors necessary for switching, proliferation, I or differentiation of IgA B cells.

Keywords

Cell Clone Mesenteric Lymph Node Keyhole Limpet Hemocyanin Peripheral Lymph Node Cognate Interaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • J. M. Phillips-Quagliata
    • 1
  • A. A. Maghazachi
    • 1
  1. 1.Department of Pathology and Kaplan Cancer CenterNew York University Medical CenterNew YorkUSA

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