T Cell Clones that Help IgA Responses
I The predominance of IgA in mucosal secretions contrasting with that I of IgG in serum, is commonly thought to reflect the unique life history I of lamina propria IgA plasma cell precursors in the mucosa-associated lymphoid tissue (MALT), especially the gut-associated lymphoid tissue (GALT). I GALT lymphoid nodules seem to provide a milieu in which commitment of B I cells to IgA production is especially favored. While many aspects of this I milieu could theoretically contribute to promoting IgA at the expense of I other isotypes, one of the more attractive hypotheses is that GALT lymphoid I nodules contain higher numbers, relative to other lymphoid organs, of T I cells capable of producing factors necessary for switching, proliferation, I or differentiation of IgA B cells.
KeywordsCell Clone Mesenteric Lymph Node Keyhole Limpet Hemocyanin Peripheral Lymph Node Cognate Interaction
Unable to display preview. Download preview PDF.
- 11.Seman, M. and Morisset, J., in Recent Advances In Mucosal Immunity, (Edited by Strober, W., Hanson, L.A. and Sell, K.W.), p. 131, Raven Press, New York, 1982.Google Scholar
- 21.Dresser, D.W., in Handbook of Experimental Immunology, Vol. 2, (Edited by Weir, D.M.), p. 28.1, Blackwell Scientific, Oxford, 1978.Google Scholar