Isotype Specific Immunoregulation: Role of FcαR+ T Cells and IBFα in IgA Responses

  • T. Kurita
  • H. Kiyono
  • M. L. McGhee
  • J. R. McGhee
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 216 A)


T cell subsets which express Fc receptors for immunoglobulin (FcR) are important in isotype-specific regulation of B cell responses (1). These FcR+ T cells secrete isotype-specific immunoglobulin binding factors (IBF) which recognize specific Fc regions of immunoglobulin (Ig) and IBF can up or down regulate B cell antibody synthesis in these Ig classes. In this regard, allo-activated T cells which bear Fc receptors for IgG (FcγR) and the T2D4 T cell line (FcγR+ and FcαR+) release IgG binding factor (IBFγ) and suppress this isotype for in vitro responses (2). In the IgE system, Fc receptors for IgE (FcεR) occur on T cells which regulate this isotype response via production of either enhancing or suppressive IgE binding factors (IBFε) (3). Both potentiating and suppressive IBFε are similar in size (Mr ~15,000). They contain a common protein core, and the degree of glycosylation determines whether IBFε enhances or suppresses the IgE responses.


Cell Membrane Fraction Solubilized Membrane Fraction Murine Myeloma Cell Line Solubilized Cell Membrane Chain Specific Antibody 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • T. Kurita
    • 1
  • H. Kiyono
    • 2
  • M. L. McGhee
    • 1
  • J. R. McGhee
    • 1
  1. 1.Departments of Microbiology, The Institute of Dental ResearchUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.Oral Biology and Preventive Dentistry, The Institute of Dental ResearchUniversity of Alabama at Birmingham BirminghamBirminghamUSA

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