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Plant Vacuoles pp 485-494 | Cite as

Production of Secondary Metabolites in Cell Cultures of Some Terpenoid-Indole Alkaloids Producing Plants

  • R. Verpoorte
  • R. Wijnsma
  • P. A. A. Harkes
  • H. J. G. ten Hoopen
  • J. J. Meijer
  • W. M. Van Gulik
Part of the NATO ASI Series book series (NSSA, volume 134)

Abstract

Within the group of terpenoid-indole alkaloids and related compounds quite a few have pharmaceutical interest. As most of them have quite high prices on the market, the production by means of biotechnological processes seems attractive. Thus in the past years a number of studies have been dealing with plant cell, tissue and organ cultures of terpenoid-indole alkaloids producing plants from genera like Rauwolfia, Catharanthus, Vinca, Tabernaemontana, Voacanga, Amsonia and Cinchona. Three of these are at present studied in our Biotechnology Delft Leiden (BDL) project group, viz. Catharanthus, Tabernaemontana and Cinchona with the aim to improve yields of alkaloids in the cell cultures. Recently we have reviewed the work on Cinchona cell cultures (Verpoorte et al., 1985; Wijnsma and Verpoorte, 1986 e). Here we shall confine ourselves to a brief review of some of the results recently in our laboratories.

Keywords

Cell Suspension Culture Alkaloid Production Cinchona Alkaloid Plant Cell Report Continuous Culture System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • R. Verpoorte
    • 1
  • R. Wijnsma
    • 1
  • P. A. A. Harkes
    • 2
  • H. J. G. ten Hoopen
    • 3
  • J. J. Meijer
    • 3
  • W. M. Van Gulik
    • 3
  1. 1.Center for Bio-Pharmaceutical SciencesState University of LeidenLeidenThe Netherlands
  2. 2.Department of Plant Molecular BiologyState University of LeidenLeidenThe Netherlands
  3. 3.Department of Biochemical EngineeringDelft University of TechnologyDelftThe Netherlands

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