Abstract
Within the group of terpenoid-indole alkaloids and related compounds quite a few have pharmaceutical interest. As most of them have quite high prices on the market, the production by means of biotechnological processes seems attractive. Thus in the past years a number of studies have been dealing with plant cell, tissue and organ cultures of terpenoid-indole alkaloids producing plants from genera like Rauwolfia, Catharanthus, Vinca, Tabernaemontana, Voacanga, Amsonia and Cinchona. Three of these are at present studied in our Biotechnology Delft Leiden (BDL) project group, viz. Catharanthus, Tabernaemontana and Cinchona with the aim to improve yields of alkaloids in the cell cultures. Recently we have reviewed the work on Cinchona cell cultures (Verpoorte et al., 1985; Wijnsma and Verpoorte, 1986 e). Here we shall confine ourselves to a brief review of some of the results recently in our laboratories.
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References
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Verpoorte, R., Wijnsma, R., Harkes, P.A.A., ten Hoopen, H.J.G., Meijer, J.J., Van Gulik, W.M. (1987). Production of Secondary Metabolites in Cell Cultures of Some Terpenoid-Indole Alkaloids Producing Plants. In: Marin, B. (eds) Plant Vacuoles. NATO ASI Series, vol 134. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5341-6_62
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DOI: https://doi.org/10.1007/978-1-4684-5341-6_62
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