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Membrane Receptors, Dynamics, and Energetics pp 59–66Cite as

Mechanisms of Signal Transduction by Growth Factor Receptors

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Part of the book series: NATO ASI Series ((NSSA,volume 133))

Abstract

Immediate consequences of growth factor-receptor interaction include tyrosine-specific protein phosphorylations, inositol lipid breakdown and changes in cytoplasmic pH (pHi) and in the level of free Ca2+. The rise in pHi has a permissive effect on DNA synthesis and is mediated by Na+/H+ exchanger in the plasma membrane, which is turned on by protein kinase C. The Ca2+ signal is generated through the inositol lipid pathway and may contribute to the expression of certain proto-oncogenes. Monoclonal antibodies to the epidermal growth factor receptor can act as partial agonists in that they can induce tyrosine kinase activity without inducing inositol lipid breakdown and ionic changes. These antibodies fail to induce DNA synthesis, suggesting that tyrosine kinase activation is not sufficient for stimulation of cell proliferation.

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Authors and Affiliations

  1. Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands

    W. H. Moolenaar, L. H. K. Defize, B. C. Tilly, A. J. Bierman & S. W. de Laat

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  1. W. H. Moolenaar
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  2. L. H. K. Defize
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  3. B. C. Tilly
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  4. A. J. Bierman
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  5. S. W. de Laat
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Editors and Affiliations

  1. Laboratory of Biochemistry, State University of Utrecht, Utrecht, The Netherlands

    K. W. A. Wirtz

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© 1987 Plenum Press, New York

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Moolenaar, W.H., Defize, L.H.K., Tilly, B.C., Bierman, A.J., de Laat, S.W. (1987). Mechanisms of Signal Transduction by Growth Factor Receptors. In: Wirtz, K.W.A. (eds) Membrane Receptors, Dynamics, and Energetics. NATO ASI Series, vol 133. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5335-5_4

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  • DOI: https://doi.org/10.1007/978-1-4684-5335-5_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5337-9

  • Online ISBN: 978-1-4684-5335-5

  • eBook Packages: Springer Book Archive

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