Metabolism of Lyso(bis)Phosphatidic Acid in Rabbit Alveolar Macrophages
Lyso (bis)phosphatidic acid [L(bis)PA] is a phosphatidyl glycerol isomer with one fatty acid esterified to each glycerol moiety. This novel phospholipid was first identified by Body and Gray (1), and has since been found in a variety of mammalian tissues (2–5), normally comprising less than 1% of the total cellular lipid phosphorus. It appears that the stereochemistry of the lipid is unique, having the phosphoester bonds attached to the sn-1 carbons of each glycerol (6,7). The possible functional role of this lipid is only beginning to be understood.
KeywordsArachidonic Acid High Pressure Liquid Chromatography Phosphatidic Acid Phosphatidic Acid Glycerol Moiety
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