Advertisement

Inositol Lipid Metabolism: A Topological Point of View

  • G. Mauco
  • Ph. Dajeans
  • H. Chap
  • L. Douste-Blazy
Part of the NATO ASI Series book series (NSSA, volume 133)

Abstract

Since its discovery, the so-called “phospholipid effect” has deserved a great deal of investigations (for reviews see J. Williamson’s and K.W.A. Wirtz’s chapters in this book and ref.1–4), leading to the widely accepted scheme of inositol-1,4,5-trisphosphate (IP3) and diacylglyeerol (DG) production as second messengers of hormone action. As discussed elsewhere in this book, this dual pathway leads to increase the cytosolic free calcium concentration on one hand and to the activation of protein kinase C on the other. However, most of the studies described the overall effect of hormonereceptor interaction at the plasma membrane on the metabolic changes of inositol-phospholipids of the whole cell. It was then considered that inositol lipids were a homogeneous entity, ignoring possible subcellular compartmentation of metabolically different pools. The existence of microdomains on the plasma membrane is not documented either even if some data suggest the existence of agonist-linked pools. The aim of this chapter is to review the presently available data concerning the topology of inositollipid metabolism.

Keywords

Human Platelet Cytosolic Phospholipase Human Erythrocyte Membrane Rabbit Platelet Inositol Lipid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    R.H. Michell, Inositolphospholipids and cell surface receptor function, Biochim. Biophys. Acta 415:81 (1975).PubMedGoogle Scholar
  2. 2.
    M.J. Berridge, Inositol trisphosphate and diacylglycerol as second messenger, Biochem. J. 220:345 (1984).PubMedGoogle Scholar
  3. 3.
    J.R. Williamson, Role of inositol lipid breakdown in the generation of intracellular signals. State of the art lecture, Hypertension 8:II 140 (1986).Google Scholar
  4. 4.
    L.E. Hokin, Receptors and phosphoinositide-generated second messengers, Annu. Rev. Biochem. 54:205 (1985).PubMedCrossRefGoogle Scholar
  5. 5.
    G. Mauco, C.A. Dangelmaier and J.B. Smith, Insotiol lipids, phosphatidate and diacylglycerol share stearoyl-arachidonoyl-glycerol as a common backbone in thrombin-stimulated human platelets, Biochem. J. 224:933 (1984).PubMedGoogle Scholar
  6. 6.
    H.D. Griffin and J.N. Hawthorne, Calcium activated hydrolysis of phosphatidyl-myo-inositol 4-phosphate and phosphatidyl-myo-inositol 4,5-bisphosphate in guinea pig synaptosomes, Biochem. J. 176:541 (1978).PubMedGoogle Scholar
  7. 7.
    A.J. Rawyler, B. Roelofsen, K.W.A. Wirtz and J.A.F. Op den Kamp, (poly) Phosphoinositide phosphorylation is a marker for plasma membrane in Friend erythroleukaemic cells, FEBS Lett. 148:140 (1982).PubMedCrossRefGoogle Scholar
  8. 8.
    M.A. Seyfred and W.W. Wells, Subcellular incorporation of 32P into phosphoinositides and other phospholipids in isolated hepatocytes, J. Biol. Chem. 259:7659 (1984).PubMedGoogle Scholar
  9. 9.
    M.A. Seyfred and W.W. Wells, Subcellular site of vasopressin-stimulated hydrolysis of phosphoinositides in rat hepatocytes, J. Biol. Chem. 259:7666 (1984).PubMedGoogle Scholar
  10. 10.
    G. Mauco, Ph. Dajeans, H. Chap and L. Douste-Blazy, Subcellular localization of inositol lipids in blood platelets as deduced from the use of labelled precursors. Submitted for publication.Google Scholar
  11. 11.
    J. Fauvel, H. Chap, V. Roques, S. Lévy-Tolédano and L. Douste-Blazy, Biochemical characterization of plasma membranes and intracellular membranes isolated from human platelets using Percoll gradients, Biochim. Biophys. Acta 236, 176 (1986).Google Scholar
  12. 12.
    H. Chap, R.F.A. Zwaal and L.L.M. van Deenen, Action of highly purified phospholipases on blood platelets. Evidence for asymmetric distribution of phospholipids in the surface membrane, Biochim. Biophys. Acta 467:146 (1977).PubMedCrossRefGoogle Scholar
  13. 13.
    B. Perret, H. Chap and L. Douste-Blazy, Asymmetric distribution of arachidonic acid in the plasma membrane of human platelets. A determination using purified phospholipases and a rapid method for membrane isolation, Biochim. Biophys. Acta 556:434 (1979).PubMedCrossRefGoogle Scholar
  14. 14.
    R.F.A. Zwaal, R. Roelofsen, P. Comfurius and L.L.M. van Deenen, Organization of phospholipid in human red cell membranes as detected by the action of various purified phospholipases, Biochim. Biophys. Acta 406: 83 (1975).PubMedCrossRefGoogle Scholar
  15. 15.
    R.J.B. Garret and C.M. Redman, Localization of enzymes involved in polyphosphoinositide metabolism on the cytoplasmic surface of the human erythrocyte membrane, Biochim. Biophys. Acta 382:58 (1975).CrossRefGoogle Scholar
  16. 16.
    M. Lagarde, M. Guichardant, 5. Menashi and N. Crawford, The phospholipid and fatty acid composition of human platelet surface and intracellular membranes isolated by high voltage free flow electrophoresis, J. Biol. Chem. 257:3100 (1982).PubMedGoogle Scholar
  17. 17.
    F. Zambrano, S. Fleisher and B. Fleisher, Lipid composition of the Golgi apparatus of rat kidney and liver in comparison with other subcellular organelles, Biochim. Biophys. Acta 380:357 (1975).PubMedGoogle Scholar
  18. 18.
    C.D. Smith and W.W. Wells, Characterization of a phosphatidylinositol 4-phosphate-specific Phosphomonoesterase in rat liver nuclear envelopes, Arch. Biochem. Biophys. 235:529 (1984).PubMedCrossRefGoogle Scholar
  19. 19.
    B. Jergil and R. Sundler, Phosphorylation of phosphatidylinositol in rat liver Golgi, J. Biol. Chem. 258, 7969 (1983).Google Scholar
  20. 20.
    C.R. Campbell, J.B. Fishman and R.E. Fine, Coated vesicles contain a phosphatidylinositol kinase, J. Biol. Chem. 260:10948 (1985).PubMedGoogle Scholar
  21. 21.
    G.A. Lundberg, B. Jergil and R. Sundler, Subcellular localization and enzymatic properties of rat liver phosphatidylinositol-4-phosphate kinase, Biochim. Biophys. Acta 846:379 (1985).PubMedCrossRefGoogle Scholar
  22. 22.
    H.D. Kaulen and R. Gross, Metabolic properties of human platelet membranes. II. Thrombin-induced phosphorylation of membrane-lipids and demonstration of phosphorylating enzymes in the platelet membrane, Thromb. Haemost. 35:364 (1976).PubMedGoogle Scholar
  23. 23.
    F.L. II Call and M. Rubert, Diglyceride kinase in human platelets, J. Lipid Res. 14:466 (1973).PubMedGoogle Scholar
  24. 24.
    J.D. Esko and C.R.H. Raetz, Synthesis of phospholipids in animal cells, Enzymes 16:206 (1983).Google Scholar
  25. 25.
    W. Thompson and G. MacDonald, Synthesis of molecular classes of cytidine diphosphate diglyceride by rat liver in vivo and in vitro, Can. J. Biochem. 55:1153 (1977).PubMedCrossRefGoogle Scholar
  26. 26.
    H. Paulus and E.P. Kennedy, The enzymatic synthesis of inositol monophosphatide, J. Biol. Chem. 235:1303 (1960).PubMedGoogle Scholar
  27. 27.
    T. Takenawa and K. Egawa, CDP-diglyceride: inositol transferase from rat liver, J. Biol. Chem. 252:5419 (1977).PubMedGoogle Scholar
  28. 28.
    G. M. Helmkamp Jr., Phosphatidylinositol transfer protein: structure, catalytic activity and physiological function, Chem. Phys. Lipids 38:3 (1985).PubMedCrossRefGoogle Scholar
  29. 29.
    F. Laffont, H. Chap, G. Soula and L. Douste-Blazy, Phospholipid exchange proteins from platelet cytosol possibly involved in phospholipid effect. Biochem. Biophys. Res. Commun. 102:1366 (1981).PubMedCrossRefGoogle Scholar
  30. 30.
    P.Y. George and C.M. Helmkamp Jr., Purification and characterization of a phosphatidylinositol transfer protein from human platelets, Biochim. Biophys. Acta 836:176 (1985).PubMedGoogle Scholar
  31. 31.
    D. Allan and R.H. Michell, Phosphatidylinositol cleavage catalysed by the soluble fraction from lymphocytes. Activity of pH 5.5 and pH 7.0, Biochem. J. 142:599 (1974).PubMedGoogle Scholar
  32. 32.
    C. Mauco, H. Chap and L. Douste-Blazy, Characterization and properties of a phosphatidylinositol phosphodiesterase (phospholipase C) from platelet cytosol, FEBS Lett. 100:367 (1979).PubMedCrossRefGoogle Scholar
  33. 33.
    S.E. Rittenhouse-Simmons, Production of diglyceride from phosphatidylinositol in activated human platelets, J. Clin. Invest. 63:580 (1979).PubMedCrossRefGoogle Scholar
  34. 34.
    S.E. Rittenhouse, Human platelets contain phospholipase C that hydrolyses polyphosphoinositides, Proc. Natl. Acad. Sci. US 80:5417 (1983).CrossRefGoogle Scholar
  35. 35.
    W. Siess and E.G. Lapetina, Properties and distribution of phosphatidylinositol — specific phospholipase C in human and horse platelets, Biochim. Biophys. Acta 752:329 (1983).PubMedGoogle Scholar
  36. 36.
    M. Plantavid, L. Rossignol, H. Chap and L. Douste-Blazy, Studies on endogenous polyphosphoinositide hydrolysis in human platelet membranes. Evidence that polyphosphoinositide remain unaccessible to phosphodiesterase in the native membrane, Biochim. Biophys. Acta 875:147(1986).Google Scholar
  37. 37.
    H. M’Zali and F. Giraud, Phosphoinositide reorganization in human erythrocyte membrane upon cholesterol depletion, Biochem. J., 234:13 (1986).PubMedGoogle Scholar
  38. 38.
    R.J. Uhing, H. Jiang, V. Prpic and J.H. Exton, Regulation of a liver plasma membrane phosphoinositide phosphodiesterase by guanine nucleotides and calcium, FEB5 Lett. 118:317 (1985).CrossRefGoogle Scholar
  39. 39.
    J.J. Baldassare and G.J. Fisher, GTP and cytosol stimulate phosphoinositide hydrolysis in isolated membranes, Biochem. Biophys. Res. Commun. 137: 801 (1986).PubMedCrossRefGoogle Scholar
  40. 40.
    J.J. Baldassare and G.J. Fisher, Regulation of membrane-associated and cytosolic phospholipase C activities in human platelets by guanosine triphosphate, J. Biol. Chem. 261:11942 (1986).PubMedGoogle Scholar
  41. 41.
    Y. Banno, S. Nakashima, T. Tohmatsu, Y. Nozawa and E.G. Lapetina, GTP and GDP will stimulate platelet cytosolic phospholipase C independently of Ca2+, Biochem. Biophys. Res. Commun. 140, 128 (1986).CrossRefGoogle Scholar
  42. 42.
    R.S. Rana, R.J. Mertz, A. Kowluru, J.F. Dixon, L.E. Hokin and M.J. Mac Donald, Evidence for glucose-responsive and un-responsive pools of phospholipid in pancreatic islets, J. Biol. Chem. 260:7861 (1985).PubMedGoogle Scholar
  43. 43.
    R.S. Rana, A. Kowluru and M.J. MacDonald, Secretagogue-responsive and unresponsive pools of phosphatidylinositol in pancreatic islets, Arch. Biochem. Biophys. 245:411 (1986).PubMedCrossRefGoogle Scholar
  44. 44.
    D.D. Schoepp, Manganese stimulates the incorporation of (3H) inositol into a pool of phosphatidylinositol in brain that is not coupled to agonist-induced hydrolysis, J. Neurochem. 45:1481 (1985).PubMedCrossRefGoogle Scholar
  45. 45.
    M.E. Monaco, The phosphatidylinositol cycle in WRK-1 cells, evidence for a separate, hormone-sensitive phosphatidylinositol pool. J. Biol. Chem. 257:2137 (1982).PubMedGoogle Scholar
  46. 46.
    K. Koreh and M.E. Monaco, The relationship of hormone-sensitive and hormone-insensitive phosphatidylinositol to phosphatidylinositol 4,5-bisphosphate in the WRK-1 cell, J. Biol. Chem. 261:88 (1986).PubMedGoogle Scholar
  47. 47.
    J.D. Vickers, M. Kinlough-Rathbone and J.F. Mustard, Changes in phosphatidylinositol-4,5-bisphosphate 10 seconds after stimulation of washed rabbit platelets with ADP, Biochem. Biophys. Res. Commun. 133: 98 (1982).Google Scholar
  48. 48.
    G. Mauco, H. Chap and L. Douste-Blazy, Platelet activating factor (PAF-acether) promotes an early degradation of phosphatidylinositol-4,5-bisphosphate in rabbit platelets, FEBS Lett. 153:361 (1983).PubMedCrossRefGoogle Scholar
  49. 49.
    J.M. Broekman, J.W. Ward and A.J. Marcus, Fatty acid composition of phosphatidylinositol and phosphatidic acid in stimulated platelets. Persistence of arachidonoyl-stearyl structure, J. Biol. Chem. 256: 8271 (1981).PubMedGoogle Scholar
  50. 50.
    I. Lassing and U. Lindberg, Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin, Nature 314:472 (1985).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • G. Mauco
    • 1
  • Ph. Dajeans
    • 1
  • H. Chap
    • 1
  • L. Douste-Blazy
    • 1
  1. 1.INSERM Unité 101, Biochimie des LipidesHôpital PurpanToulouse CédexFrance

Personalised recommendations