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Genetic Basis of Membrane Phospholipid Diversity: A Summary

  • Christian R. H. Raetz
Part of the NATO ASI Series book series (NSSA, volume 133)

Abstract

The long-range goal of this research is the elucidation of the organization and properties of the genes coding for the enzymes of membrane phospholipid synthesis in animal cells. When this work was initiated in 1978, animal cell mutants defective in membrane phospholipid synthesis had not been described.1 Much of the initial effort in my laboratory was directed towards the development of procedures for the isolation of such mutants.1–3 The discovery of the ability of Chinese hamster ovary cells to form macroscopic colonies on filter paper1 or polyester cloth3 has made it possible to perform high resolution replica plating and rapid biochemical sorting of animal cell colonies. This methodology has yielded. several biochemically defined mutants, including strains defective in the biosynthesis of phosphatidylcholine,4–6 phosphatidylethanolamine,7 phosphatidylserine8,9 and plasmalogens.10

Keywords

Animal Cell Chinese Hamster Ovary Phosphatidic Acid Polyester Cloth3 Dihydroxyacetone Phosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Christian R. H. Raetz
    • 1
  1. 1.Department of BiochemistryUniversity of Wisconsin-MadisonMadisonUSA

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