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Inositol Lipid Metabolism: Generation of Second Messengers

  • John R. Williamson
  • Carl A. Hansen
Part of the NATO ASI Series book series (NSSA, volume 133)

Abstract

It is generally accepted that the regulation of characteristic functions specific for different cells is brought about by the binding of agonists and hormones to receptor proteins located in the plasma membrane (1). Transfer of information from chemicals in the extracellular environment to the regulation of many intracellular enzymes and proteins is achieved by a number of different receptor-dependent signalling mechanisms. The best understood example of such a process is the β-adrenergic activation of adenylate cyclase, which causes an increased production of cAMP as a second messenger (2). The subsequent activation of cAMP-dependent protein kinase results in the phosphorylation and modulation of the activity of a variety of target enzymes and regulatory proteins within the cell with consequent alterations of specific cell functions (3).

Keywords

High Performance Liquid Chromatography Adenylate Cyclase Pertussis Toxin Inositol Phosphate Inositol Polyphosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • John R. Williamson
    • 1
  • Carl A. Hansen
    • 1
  1. 1.Department of Biochemistry and BiophysicsUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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