Incorporation of GABA/Benzodiazepine Receptors into Natural Brain Lipid Liposomes: Biochemical Characterization

  • David R. Bristow
  • Ian L. Martin
Part of the NATO ASI Series book series (NSSA, volume 133)


γ-aminobutyric acid (GABA) is one of the major inhibitory neurotransmitters in mammalian CNS. Its action is mediated through two pharmacologically distinct receptor subtypes designed GABAA and GABAB. Interaction of GABA with the former opens anion channels, located in cell membranes, which allow the passage of chloride ions down their electrochemical gradient; this generally leads to membrane hyperpolarisation. This receptor is therefore amenable to functional analysis using biochemical and electrophysiological techniques. Such analysis should elucidate the mechanism of ligand-induced regulation of the anion channel at the molecular level, identify the minimum subunit requirements for function and provide further physiochemical information on the GABAA receptor complex.


Receptor Complex Anion Channel Ammonium Molybdate Unilamellar Liposome Major Inhibitory Neurotransmitter 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • David R. Bristow
    • 1
  • Ian L. Martin
    • 1
  1. 1.MRC Molecular Neurobiology UnitUniversity of Cambridge Medical SchoolCambridgeUK

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