Defining the Roles of Growth Factors during Early Mammalian Development

  • Angie Rizzino


It is universally accepted that differential gene expression is central to the regulation of embryonic development. In reality, very little is known about the genes involved and how their expression is modulated. Although important regulatory genes are likely to be expressed during early development in response to environmental cues generated by the interactions of cells, even less is known about these events [see Chapter 7 (Ed.)]. Environmental cues that regulate cell behavior can take various forms, including: direct cell-cell contact, interactions with extracellular matrices, and interactions with diffusible factors. Diffusible factors can function over both short and long distances. Consequently, diffusible factors can be expected to affect the behavior of many cells and, in all probability, each factor affects the behavior of more than one cell type.


High Density Lipoprotein Inner Cell Mass Embryonal Carcinoma Cell Mouse Blastocyst Extraembryonic Endoderm 
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© Plenum Press, New York 1987

Authors and Affiliations

  • Angie Rizzino
    • 1
  1. 1.Eppley Institute for Research in Cancer and Related DiseasesUniversity of Nebraska Medical CenterOmahaUSA

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