Analysis of Embryotoxic Effects in Preimplantation Embryos

  • Horst Spielmann


In human pregnancy, it has been particularly difficult to obtain data on the action of drugs and environmental chemicals during the period before implantation of the embryo in the uterus. Scientific interest in the action of xenobiotics in early pregnancy is focusing on the earliest stage of gestation since recent epidemiological evaluations are not only indicating that 60% to 75% of all fertilized oocytes are dying during normal pregnancy but moreover that 50% of them are already dying before implantation (Biggers, 1981; Kline and Stein, 1985). This view is supported by the experience with human in vitro fertilization, which even in the most proficient hands has a low survival rate of embryos that are transferred back to the mother (Edwards and Steptoe, 1983).


Mouse Embryo Sister Chromatid Exchange Inner Cell Mass Preimplantation Embryo Cleavage Stage Embryo 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Horst Spielmann
    • 1
  1. 1.Max v. Pettenkofer- InstitutBundesgesundheitsamt (BGA)1 Berlin 33West Germany

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