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Side Chain Conformations of Somatostatin Analogs when Bound to Receptors

  • Ruth F. Nutt
  • C. Dylion Colton
  • Richard Saperstein
  • Daniel F. Veber
Part of the Serono Symposia, USA book series (SERONOSYMP)

Abstract

Conformationally based design has resulted in greatly simplified constrained analogs of somatostatin which show a high degree of metabolic stability and improved duration of action.

Keywords

Upfield Shift Lysine Side Chain Side Chain Conformation Cyclic Hexapeptide Pept Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Ruth F. Nutt
    • 1
  • C. Dylion Colton
    • 1
  • Richard Saperstein
    • 1
  • Daniel F. Veber
    • 1
  1. 1.Merck Sharp & Dohme Research LaboratoriesWest PointUSA

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