Cotranslational and Posttranslational Proteolytic Processing of Preprosomatostatin-I and Preprosomatostatin-II in Intact Islet Tissue

  • Bryan D. Noe
  • Robert B. Mackin
  • John K. McDonald
  • Philip C. Andrews
  • Jack E. Dixon
  • Joachim Spiess
Part of the Serono Symposia, USA book series (SERONOSYMP)


Somatostatin-14 (SS-14) and somatostatin-28 (SS-28) are synthesized as part of a larger precursor, prosomatostatin. This has been demonstrated by results from experiments employing pulse-chase incubations or chemical characterization of products from intact tissue (1–9).


Pancreatic Islet Medullary Thyroid Carcinoma Cleavage Product Islet Tissue Biosynthetic Study 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Bryan D. Noe
    • 1
  • Robert B. Mackin
    • 1
  • John K. McDonald
    • 1
  • Philip C. Andrews
    • 2
  • Jack E. Dixon
    • 2
  • Joachim Spiess
    • 3
  1. 1.Department of Anatomy and Cell BiologyEmory University School of MedicineAtlantaUSA
  2. 2.Department of BiochemistryPurdue UniversityWest LafayetteUSA
  3. 3.The Salk InstituteClayton Foundation Laboratories for Peptide BiologyLa JollaUSA

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