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Cotranslational and Posttranslational Proteolytic Processing of Preprosomatostatin-I and Preprosomatostatin-II in Intact Islet Tissue

  • Bryan D. Noe
  • Robert B. Mackin
  • John K. McDonald
  • Philip C. Andrews
  • Jack E. Dixon
  • Joachim Spiess
Part of the Serono Symposia, USA book series (SERONOSYMP)

Abstract

Somatostatin-14 (SS-14) and somatostatin-28 (SS-28) are synthesized as part of a larger precursor, prosomatostatin. This has been demonstrated by results from experiments employing pulse-chase incubations or chemical characterization of products from intact tissue (1–9).

Keywords

Pancreatic Islet Medullary Thyroid Carcinoma Cleavage Product Islet Tissue Biosynthetic Study 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Bryan D. Noe
    • 1
  • Robert B. Mackin
    • 1
  • John K. McDonald
    • 1
  • Philip C. Andrews
    • 2
  • Jack E. Dixon
    • 2
  • Joachim Spiess
    • 3
  1. 1.Department of Anatomy and Cell BiologyEmory University School of MedicineAtlantaUSA
  2. 2.Department of BiochemistryPurdue UniversityWest LafayetteUSA
  3. 3.The Salk InstituteClayton Foundation Laboratories for Peptide BiologyLa JollaUSA

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