Regulation of Somatostatin Gene Expression by Cyclic AMP

  • Richard H. Goodman
  • Gail Mandel
  • Kevin A. Sevarino
  • Marc R. Montminy
Part of the Serono Symposia, USA book series (SERONOSYMP)


The work of Sutherland, Rall, and colleagues in the 1950’s firmly established the role of cyclic AMP as an important regulator of cellular processes.


PC12 Cell Bovine Leukemia Virus Transcriptional Initiation Site Medullary Thyroid Carcinoma Cell Transfected PC12 Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Reichlin S. Somatostatin. N Engl J Med 1983; 309: 1495–501.PubMedCrossRefGoogle Scholar
  2. 2.
    Delfs J, Robbins RJ, Connolly M, Dichter M, Reichlin S. Somatostatin production by rat cerebral neurons in dissociated cell culture. Nature 1980; 283: 676–7.PubMedCrossRefGoogle Scholar
  3. 3.
    Montminy MR, Low MJ, Tapia-Arancibia L, Reichlin S, Mandel G, Goodman RH. Cyclic AMP regulates somatostatin mRNA accumulation in primary diencephalic cultures and in transfected fibroblast cells. J Neurosci 1986; 6: 1171–6.PubMedGoogle Scholar
  4. 4.
    Graham F, Van der Eb AJ. A new technique for the assay of human adenovirus 5 DNA. Virology 1973; 52: 456–67.PubMedCrossRefGoogle Scholar
  5. 5.
    Southern P, Berg P. Mammalian cell transformation with SV40 hybrid plasmid vectors. Mol Appl Genetics 1982; 1: 327–33.Google Scholar
  6. 6.
    Tischler AS, Greene L. Nerve growth factor-induced process formation by cultured rat pheochromocytoma cells. Nature 1975; 258: 341–2.PubMedCrossRefGoogle Scholar
  7. 7.
    Potter H, Weir L, Leder P. Enhancer-dependent expression of human k immunoglobulin genes introduced into mouse pre-ß lymphocytes by electroporation. Proc Natl Acad Sci USA 1984; 81: 7161–5.PubMedCrossRefGoogle Scholar
  8. 8.
    Laimins L, Gruss P, Pozzatti R, Khoury G. Characterization of the enhancer elements in the long terminal repeat of the Maloney murine sarcoma virus. J Virol 1984; 49: 183–9.PubMedGoogle Scholar
  9. 9.
    Short JM, Wynshaw-Boris A, Short HP, Hanson RW. Characterization of the phosphenolpyruvate carboxykinase promoter regulatory region. J Biol Chem 1986; 261: 9721–6.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Richard H. Goodman
    • 1
  • Gail Mandel
    • 1
  • Kevin A. Sevarino
    • 1
  • Marc R. Montminy
    • 2
  1. 1.Division of Molecular Medicine, Department of MedicineTufts-New England Medical CenterBostonUSA
  2. 2.Peptide Biology LaboratorySalk InstituteLa JollaUSA

Personalised recommendations