Advertisement

Somatostatin pp 267-273 | Cite as

Somatostatin in Gastrointestinal Function: Intestinal Absorption and Secretion

  • Kiertisin Dharmsathaphorn
Part of the Serono Symposia, USA book series (SERONOSYMP)

Abstract

Somatostatin, a 14-amino acid peptide with a growth hormone release inhibition property, was initially isolated from sheep hypothalami (1). Later, the peptide was isolated or detected in many organ systems of all mammalians as well as lower animals.

Keywords

Carcinoid Syndrome Electrolyte Transport Rabbit Ileum Cyclic Hexapeptide Transport Potency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Brazeau P, Vale W, Burgus R, et al. Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science 1973; 179: 77.PubMedCrossRefGoogle Scholar
  2. 2.
    Polak JM, Pearse AGE, Grimelius L, Bloom SR, Arimura A. Growth hormone release-inhibiting hormone in gastrointestinal and pancreatic D cells. Lancet 1977; 1: 1220.Google Scholar
  3. 3.
    Ferri G-L, Adrian TE, Ghatei MA, et al. Tissue localization and relative distribution of regulatory peptides in separated layers from the human bowel. Gastroenterology 1983; 84: 777.PubMedGoogle Scholar
  4. 4.
    Penman E, Wass JAH, Butler MG, et al. Distribution and characterization of immunoreactive somatostatin in human gastrointestinal tract. Regul Pept 1983; 7: 53.PubMedCrossRefGoogle Scholar
  5. 5.
    Hokfelt T, Schultzberg M, Johansson O, et al. Central and peripheral peptide producing neurons. In: Bloom SR, ed. Gut hormones. Edinburgh: Churchill Livingstone, 1978: 423.Google Scholar
  6. 6.
    Uvnas-Wallenstein K, Efendic S, Luft R. The occurrence of somatostatin-like immunoreactivity in the vagal nerves. Acta Physiol Scand 1978; 102: 248.CrossRefGoogle Scholar
  7. 7.
    Konturek SJ, Tasler J, Cieszkowski M, Coy DH, Schally AV. Effect of growth hormone release-inhibiting hormone on gastric secretion, mucosal blood flow and serum gastrin. Gastroenterology 1976; 70: 737.PubMedGoogle Scholar
  8. 8.
    Boden G, Sivitz MC, Owen EO, Essa-Koumar N, Landor JH. Somatostatin suppresses secretin and pancreatic exocrine secretion. Science 1975; 190: 163.PubMedCrossRefGoogle Scholar
  9. 9.
    Konturek SJ, Tasler J, Obtulowicz W, Coy DH, Schally AV. Effect of growth hormone-release inhibiting hormone on hormones stimulating exocrine pancreatic secretion. J Clin Invest 1976; 58: 1.PubMedCrossRefGoogle Scholar
  10. 10.
    Mitznegg P, Bloom SR, Domschke W, Domschke S, Wunsch E, Demling L. Pharmacokinetics of motilin in man. Gastroenterology 1977; 72: 413.PubMedGoogle Scholar
  11. 11.
    Kayasseh L, Haecki WH, Gyr K, et al. The endogenous release of pancreatic polypeptide by acid and meal in dogs. Scand J Gastroenterol 1978; 13: 385.PubMedCrossRefGoogle Scholar
  12. 12.
    Gerich JE, Patton GS. Somatostatin. Physiology and clinical applications. Med Clin North Am 1978; 62: 375.PubMedGoogle Scholar
  13. 13.
    Larsson LI, Goltermann N, DeMagistris L, Rehfeld JF, Schwartz TW. Somatostatin cell process as pathways for paracrine secretion. Science 1979; 205: 1393.PubMedCrossRefGoogle Scholar
  14. 14.
    Schusdziarra V, Harris V, Conlon JM, Arimura A, Unger R. Pancreatic and gastric somatostatin release in response to intragastric and intraduodenal nutrients and HC1 in the dog. J Clin Invest 1978; 62: 509.PubMedCrossRefGoogle Scholar
  15. 15.
    Penman E, Wass JAH, Medbak S, et al. Response of circulating immunoreactive somatostatin to nutritional stimuli in normal subjects. Gastroenterology 1981; 81: 692.PubMedGoogle Scholar
  16. 16.
    Rouiller D, Schusdziarra V, Conlon JM, Harris V, Unger RH. Release of somatostatin-like immunoreactivity from the lower gut. Gastroenterology 1979; 77: 700.PubMedGoogle Scholar
  17. 17.
    Dharmsathaphorn K, Sherwin RS, Dobbins JW. Somatostatin inhibits fluid secretion in the rat jejunum. Gastroenterology 1980; 78: 1554.PubMedGoogle Scholar
  18. 18.
    Carter RF, Bitar KN, Zfass AM, Makhlouf GM. Inhibition of VIP-stimulated intestinal secretion and cyclic AMP production by somatostatin in the rat. Gastroenterology 1978; 74: 726.PubMedGoogle Scholar
  19. 19.
    Dharmsathaphorn K, Racusen L, Dobbins JW. Effect of somatostatin on ion transport in the rat colon. J Clin Invest 1980; 66: 813.PubMedCrossRefGoogle Scholar
  20. 20.
    Dharmsathaphorn K, Binder HJ, Dobbins JW, Leo L. Somatostatin stimulates sodium and chloride absorption in the rabbit ileum. Gastroenterology 1980; 78: 1559.PubMedGoogle Scholar
  21. 21.
    Guandalini S, Kachur JF, Smith PL, Miller RJ, Field M. In vitro effects of somatostatin on ion transport in rabbit intestine. Am J Physiol 1980; 238: G67.PubMedGoogle Scholar
  22. 22.
    Barbezat GO, Reasbeck PG. Somatostatin inhibition of glucagonstimulated jejunal secretion in the dog. Gastroenterology 1981; 81: 471.PubMedGoogle Scholar
  23. 23.
    Dharmsathaphorn K, Sherwin RS, Cataland S, Jaffe B, Dobbins J. Somatostatin inhibits diarrhea in the carcinoid syndrome. Ann Intern Med 1980; 92: 68.PubMedCrossRefGoogle Scholar
  24. 24.
    Davis GR, Camp RC, Raskin P, Krejs GJ. Effect of somatostatin infusion on jejunal water and electrolyte transport in a patient with secretory diarrhea due to malignant carcinoid syndrome. Gastroenterology 1980; 78: 346.PubMedGoogle Scholar
  25. 25.
    Ruskone A, Rene E, Chayvialle JA, et al. Effect of somatostatin on diarrhea and on small intestinal water and electrolyte transport in a patient with pancreatic cholera. Dig Dis Sci 1982; 27: 459.PubMedCrossRefGoogle Scholar
  26. 26.
    Krejs GJ, Browne R, Raskin P. Effect of intravenous somatostatin on jejunal absorption of glucose, amino acids, water, and electrolytes. Gastroenterology 1980; 78: 26.PubMedGoogle Scholar
  27. 27.
    Dharmsathaphorn K, McRoberts JA, Mandel KG, Tisdale LD, Masui H. A human colonic tumor cell line that maintains vectorial electrolyte transport. Am J Physiol 1984; 246: G204.PubMedGoogle Scholar
  28. 28.
    Dharmsathaphorn K, McRoberts JA, Masui H, Mandel KG. VIP-induced chloride secretion by a colonic epithelia cell line: direct partic-ipation of a basolaterally localized Na+, K+,Cl cotransport system. J Clin Invest 1985; 75: 462.PubMedCrossRefGoogle Scholar
  29. 29.
    Mandel KG, McRoberts JA, Beuerlein G, Foster ES, Dharmsathaphorn K. Ba++ inhibition of VIP and A23187 stimulated Cl secretion by T84 cell monolayers. Am J Physiol 1986; 259: C486.Google Scholar
  30. 30.
    Weymer A, Huott P, McRoberts JA, Dharmsathaphorn K. Chloride secretory mechanism induced by prostaglandin E1 in a colonic epithelial cell line. J Clin Invest 1985; 76: 1828.PubMedCrossRefGoogle Scholar
  31. 31.
    Mulvihill S, Passaro E Jr, Debas H, Yamada T. Severe diarrhea after colonic pseudo-obstruction: treatment with somatostatin. N Engl J Med 1984; 310: 467.PubMedCrossRefGoogle Scholar
  32. 32.
    Dharmsathaphorn K, Gorelick FS, Sherwin RS, Cataland S, Dobbins JW. Somatostatin decreases diarrhea in patients with the short-bowel syndrome. J Clin Gastroenterol 1982; 4: 521.PubMedCrossRefGoogle Scholar
  33. 33.
    Veber DF, Freidinger RM, Schwenk Perlow D, et al. A potent cyclic hexapeptide analogue of somatostatin. Nature 1981; 292: 58.CrossRefGoogle Scholar
  34. 34.
    Murphy WA, Meyers CA, Coy DH. Potent, highly selective inhibition of growth hormone secretion by position 4 somatostatin analogs. Endocrinology 1981; 109: 491.PubMedCrossRefGoogle Scholar
  35. 35.
    Meyes CA, Coy DH, Murphy W, Redding TW, Arimura A, Schally AV. [Phe] Somatostatin: a potent, selective inhibitor of growth hormone release. Proc Natl Acad Sci USA 1980; 77: 577.CrossRefGoogle Scholar
  36. 36.
    Sarantakis D, McKinley WA, Jaunakais I, Clark D, Grant NH. Structure activity studies on somatostatin. Clin Endocrinol 1976; 5: 275.CrossRefGoogle Scholar
  37. 37.
    Brown M, Rivier J, Vale W. Somatostatin: analogs with selected biological activities. Science 1977; 196: 1467.PubMedCrossRefGoogle Scholar
  38. 38.
    Vale W, Rivier J, Brown M. Biologic and immunologic activities and applications of somatostatin analogs. Metabolism 1978; 27: 1391.PubMedCrossRefGoogle Scholar
  39. 39.
    Brown M, Rivier J, Vale W. Somatostatin: central nervous system action on glucoregulation. Endocrinology 1979; 104: 1709.PubMedCrossRefGoogle Scholar
  40. 40.
    Rosenthal LE, Yamashiro DJ, Rivier J, Vale W, Brown M, Dharmsathaphorn K. Structure-activity relationships of somatostatin analogs in the rabbit ileum and the rat colon. J Clin Invest 1983; 71: 840.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Kiertisin Dharmsathaphorn
    • 1
  1. 1.Department of MedicineUniversity of California, San Diego Medical CenterSan DiegoUSA

Personalised recommendations