Skip to main content
SpringerLink
Log in

Somatostatin Inhibits Intestinal Motility via Modulation of Cyclic AMP-Dependent Cholinergic Transmission

  • Chapter
Somatostatin

Part of the book series: Serono Symposia, USA ((SERONOSYMP))

Abstract

Somatostatin (SRIF) is a tetradecapeptide that was initially isolated from ovine hypothalamus and described as an inhibitor of growth hormone release (1).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Brazeau P, Vale W, Burgus R, et al. Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science 1973; 179: 77–9.

    Article  PubMed  CAS  Google Scholar 

  2. Vale W, Brazeau P, Rivier C, et al. Somatostatin. Recent Prog Horm Res 1975; 31: 365–97.

    CAS  Google Scholar 

  3. Hokfelt T, Johansson O, Luft R, Arimura A. Immunohistochemical evidence for the presence of somatostatin, a powerful inhibitory peptide, in some primary sensory neurons. Neurosci Lett 1975; 1: 231–5.

    Article  Google Scholar 

  4. Hokfelt T, Elfvin LG, Elde R, Schultzberg M, Goldstein M, Luft R. Occurrence of somatostatin immunoreactívity in some peripheral sympathetic nonadrenergic neurons. Proc Natl Acad Sci USA 1977; 74: 3587–91.

    Article  PubMed  CAS  Google Scholar 

  5. Hokfelt T, Efendic S, Johansson 0, Luft R, Arimura A. Immunohistochemical localization of somatostatin (growth hormone release-inhibiting factor) in the guinea pig brain. Brain Res 1974; 80: 165–9.

    Article  PubMed  CAS  Google Scholar 

  6. Costa M, Furness JB, Llewellyn-Smith IJ, Davies B, Oliver J. An immunohistochemical study of the projections of somatostatin-containing neurons in the guinea pig intestine. Neuroscience 1980; 5: 84152.

    Google Scholar 

  7. Johansson C, Efendic S, Wisen 0, Uvnas-Wallensten K, Luft R. Effects of short-term somatostatin infusion on the gastric and intestinal propulsion in humans. Scand J Gastroenterol 1978; 13: 481–3.

    Article  PubMed  CAS  Google Scholar 

  8. Lux G, Femppel J, Leaderer P. Somatostatin induces interdigestive intestinal motor and secretory complex-like activity in man. Gastroenterology 1980; 78: 1212.

    Google Scholar 

  9. Peeters TL, Janssens J, Vantrappen GR. Somatostatin and the inter-digestive migrating motor complex in man. Regul Pept 1983; 5: 209–17.

    Article  PubMed  CAS  Google Scholar 

  10. Thor P, Krol R, Konturek SJ. Effect of somatostatin on myoelectrical activity of the small bowel. Am J Physiol 1978; 235: E249–54.

    PubMed  CAS  Google Scholar 

  11. Cohen ML, Rosina E, Wiley KS, Slater IH. Somatostatin inhibits adrenergic and cholinergic neurotransmission in smooth muscle. Life Sci 1978; 23: 1659–61.

    Article  PubMed  CAS  Google Scholar 

  12. Guillemin R. Somatostatin inhibits the release of acetylcholine induced electrically in the myenteric plexus. Endocrinology 1976; 99: 1654.

    Article  Google Scholar 

  13. Furness JB, Costa M. Actions of somatostatin on excitatory and inhibitory nerves in the intestine. Eur J Pharmacol 1979; 56: 69–74.

    Article  PubMed  CAS  Google Scholar 

  14. Wu Z, Kisslinger SD, Gazinella TS. Functional evidence for the presence of cholinergic nerve endings in the colonic mucosa of the rat. J Pharmacol Exp Ther 1982; 221: 664–9.

    PubMed  CAS  Google Scholar 

  15. Gustafsson L, Hedquist P, Fredholm BB, Lundgren G. Inhibition of acetylcholine release in guinea pig ileum by adenosine. Acta Physiol Scand 1978; 104: 469–78.

    Article  PubMed  CAS  Google Scholar 

  16. Katz B. Nerve, muscle, and synapse. New York: McGraw-Hill, 1966.

    Google Scholar 

  17. Berridge MJ. Inositol trisphosphate and diacylglycerol as second messengers. Biochem J 1984; 220: 345–60.

    PubMed  CAS  Google Scholar 

  18. Berridge MJ, Irvine RF. Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature 1984; 312: 315–21.

    Article  PubMed  CAS  Google Scholar 

  19. Rasmussen H, Kojima I, Kojima K, et al. Calcium as intracellular messenger: sensitivity modulation, C-kinase pathway and sustained cellular response. Adv Cyclic Nucleotide Res 1984; 18: 159–93.

    CAS  Google Scholar 

  20. Reisine TD. Somatostatin inhibition of cyclic AMP accumulation and adenocorticotropin release from mouse anterior pituitary tumor cells: mode of action and self-regulation. Adv Cyclic Nucleotide Res 1985; 19: 169–77.

    CAS  Google Scholar 

  21. Reichlin S. Somatostatin. N Engl J Med 1983; 309: 1495–501.

    Article  PubMed  CAS  Google Scholar 

  22. Curry D, Bennett L. Does somatostatin inhibition of insulin secretion involve two mechanisms of action? Proc Natl Acad Sci USA 1976; 73: 248–51.

    Article  PubMed  CAS  Google Scholar 

  23. Koch BD, Donflinger LJ, Schonbrunn A. Pertussis toxin blocks both cyclic-AMP-mediated and cyclic AMP-independent actions of somatostatin. J Biol Chem 1985; 260: 13138–45.

    PubMed  CAS  Google Scholar 

  24. Richardson U, Schonbrunn A. Inhibition of adrenocorticotropin secretion by somatostatin in pituitary cells in culture. Endocrinology 1981; 108: 281–90.

    Article  PubMed  CAS  Google Scholar 

  25. Reisine T. Multiple mechanisms of somatostatin inhibition of adrenocorticotropin release from mouse anterior pituitary tumor cells. Endocrinology 1985; 116: 2259–66.

    Article  PubMed  CAS  Google Scholar 

  26. Palmer JM, Zafirov DH, Nemth PR, Wood JD. Peptidergic modulation of excitability in myenteric plexus neurons [Abstract]. Dig Dis Sci 1985; 30: 786.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA

    Chung Owyang & John Wiley

Authors
  1. Chung Owyang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. John Wiley
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Tufts University, Boston, Massachusetts, USA

    Seymour Reichlin M.D., Ph.D. (Chairman) (Chairman)

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer Science+Business Media New York

About this chapter

Cite this chapter

Owyang, C., Wiley, J. (1987). Somatostatin Inhibits Intestinal Motility via Modulation of Cyclic AMP-Dependent Cholinergic Transmission. In: Reichlin, S. (eds) Somatostatin. Serono Symposia, USA. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5326-3_24

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5326-3_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5328-7

  • Online ISBN: 978-1-4684-5326-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation