Somatostatin pp 239-251 | Cite as

Antral Somatostatin: A Paracrine Regulator of Gastrin Secretion

  • G. M. Makhlouf
Part of the Serono Symposia, USA book series (SERONOSYMP)


The first firm evidence for a paracrine role of somatostatin was obtained by Saffouri et al. (1) who showed that addition of somatostatin antiserum to the perfusate in the isolated vascularly perfused rat stomach produced a prompt, reversible increase in gastrin secretion (Fig. 1).


Gastric Inhibitory Polypeptide Muscarinic Agonist Vascular Perfusate Gastrin Release Gastrin Secretion 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • G. M. Makhlouf
    • 1
  1. 1.Department of Medicine, Medical College of VirginiaVirginia Commonwealth UniversityRichmondUSA

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