Somatostatin pp 229-237 | Cite as

Regulation of Somatostatin Release from Dispersed Canine Fundic D-Cells

  • Tsutomu Chiba
  • Jung Park
  • Tadataka Yamada
Part of the Serono Symposia, USA book series (SERONOSYMP)


Somatostatin, initially isolated from the ovine hypothalamus (1), has potent inhibitory actions on gastric acid secretion (2,3) and gastrin release (4,5). In the stomach, somatostatin producing D-cells are found in both fundic and antral mucosa, where they have been described as possessing long cytoplasmic processes terminating on parietal cells and gastrin-producing G cells (6,7).


Vasoactive Intestinal Polypeptide Inositol Trisphosphate Antral Mucosa Gastrin Release Fundic Mucosa 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Tsutomu Chiba
    • 1
  • Jung Park
    • 1
  • Tadataka Yamada
    • 1
  1. 1.Department of Internal MedicineUniversity of Michigan Medical SchoolAnn ArborUSA

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