Advertisement

Somatostatin pp 201-208 | Cite as

Evidence for Paracrine Function of Somatostatin

  • Werner Creutzfeldt
Part of the Serono Symposia, USA book series (SERONOSYMP)

Abstract

The title of this debate, “Somatostatin is a hormone,” and my task to question this thesis implies that I have proof against this proposition. There are numerous data supporting the hormonal role of somatostatin and I suppose that they will be presented in the next lecture.

Keywords

Antral Mucosa Gastrin Release Gastrin Secretion Paracrine Function Paracrine Secretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Berthold A: Transplantation der Hoden. Arch Anat Physiol u wiss Med 1849; 42–6.Google Scholar
  2. 2.
    Feyrter F: “Uber die peripheren endokrinen (parakrinen Drusen des Menschen.” Wien: Maudrich, 1953.Google Scholar
  3. 3.
    Pearse AGE: The endocrine cells of the GI tract: origins, morphology and functional relationships in health and disease. Clin Gastroenterol 1974; 3: 491–510.Google Scholar
  4. 4.
    Conlon JM, Bridgeman M, Alberti KGMM: The nature of big plasma somatostatin: implications for the measurement of somatostatin-like immunoreactivity in human plasma. Analyt Biochem 1982; 125: 243–52.PubMedCrossRefGoogle Scholar
  5. 5.
    Conlon JM, McCulloch AJ, Alberti KGMM: Circulating somatostatin concentrations in healthy and non-insulin-dependent (type II) diabetic subjects. Diabetes 1983; 32: 723–9.PubMedCrossRefGoogle Scholar
  6. 5a.
    Polonsky KS, Shoelson SM, Docherty HM: Plasma somatostatin-28 increases in response to feeding in man. J Clin Invest 1983; 71: 1514–8.PubMedCrossRefGoogle Scholar
  7. 5b.
    Seal A, Yamada T, Debas H, Hollinshead J, Osadchey B, Aponte G, Walsh J: Somatostatin-14 and -28: clearance and potency on gastric function in dogs. Am J Physiol 1982; 243: G97–102.PubMedGoogle Scholar
  8. 6.
    Larsson LI, Goltermann N, de Magistris L, Rehfeld JF, Schwartz TW: Somatostatin cell processes as pathways for paracrine secretion, Science 1979; 205: 1393–5.PubMedCrossRefGoogle Scholar
  9. 7.
    Alumets J, Ekelund M, El Munshid HA, Hakanson R, Loren I, Sundler F: Topography of somatostatin cells in the stomach of the rat: possible functional significance. Cell Tissue Res 1979; 202: 177–88.PubMedCrossRefGoogle Scholar
  10. 8.
    Larsson L-I: Evidence for anterograde transport of secretory granules in processes of gastric paracrine (somatostatin) cells. Histochemistry 1984; 80: 323–6.PubMedCrossRefGoogle Scholar
  11. 9.
    Grube D, Bohn R: The microanatomy of human islets of Langerhans, with special reference to somatostatin (D-) cells. Arch Histol Jpn 1983; 46: 327–53.PubMedCrossRefGoogle Scholar
  12. 10.
    Aponte G, Gross D, Yamada T: Capillary orientation of rat pancreatic D-cell processes: evidence for endocrine release of somatostatin. Am J Physiol 1985; 249: G599–606.PubMedGoogle Scholar
  13. 11.
    Grube D, Eckert I, Speck PT, Wagner H-J: Immunohistochemistry and microanatomy of the islets of Langerhans. Biomed Res 1983; 4 (suppl): 25–36.Google Scholar
  14. 12.
    Taborsky GT, Ensinck JW: Contribution of the pancreas to circulating somatostatin-like immunoreactivity in the normal dog. J Clin Invest 1984; 73: 216–23.PubMedCrossRefGoogle Scholar
  15. 13.
    Taborsky GT, Ensinck JW: Extraction of somatostatin by the pancreas. Endocrinology 1983; 112: 303–7.PubMedCrossRefGoogle Scholar
  16. 14.
    Weber M, Cole T, Conlon JM: Specific binding and degradation of somatostatin by membrane vesicles from pig gut. Am J Physiol (in press).Google Scholar
  17. 15.
    Baskin DG, Ensinck JW: Somatostatin in epithelial cells of intestinal mucosa is present primarily as somatostatin 28. Peptides 1984; 5: 615–21 (1984).CrossRefGoogle Scholar
  18. 16.
    Taniguchi H, Utsumi M, Hasegawa M, et al: Physiologic role of somatostatin. Insulin release from rat islets treated by somatostatin antiserum. Diabetes 1977; 26: 700–2.PubMedCrossRefGoogle Scholar
  19. 17.
    Itoh M, Mandarino L, Gerich JE: Antisomatostatin gamma globulin augments secretion of both insulin and glucagon in vitro. Evidence for a physiologic role for endogenous somatostatin in the regulation of pancreatic A- and B-cell function. Diabetes 1980; 29: 693–6.PubMedCrossRefGoogle Scholar
  20. 18.
    Saffouri B, Weir G, Bitar K, Makhlouf G: Stimulation of gastrin secretion from the perfused rat stomach by somatostatin antiserum. Life Sci 1979; 25: 1749–54.PubMedCrossRefGoogle Scholar
  21. 19.
    Short GM, Doyle W, Wolfe MM: Effect of antibodies to somatostatin on acid secretion and gastrin release by the isolated perfused rat stomach. Gastroenterology 1985; 88: 984–8.PubMedGoogle Scholar
  22. 20.
    Wolfe MM, Jain DK, Reel GM, McGuigan JE: Effects of carbachol on gastrin and somatostatin release in rat antral tissue culture. Gastroenterology 1984; 87: 86–93.PubMedGoogle Scholar
  23. 21.
    Kanatsuka A, Makino H, Osegawa M, Kasanuki J, Suzuki T, Yoshida S, Horse H: Is somatostatin a true local inhibitory regulator of insulin secretion? Diabetes 1984; 33: 510–5.PubMedCrossRefGoogle Scholar
  24. 22.
    Patel YC, Pierzchala I, Amherdt M, Orci L: Effects of cysteamine and antibody to somatostatin on islet cell function in vitro. J Clin Invest 1985; 75: 1249–55.PubMedCrossRefGoogle Scholar
  25. 23.
    McIntosh C, Bakich V, Trotter T, Kwok YN, Nishimura E, Pederson R, Brown J: Effect of cysteamine on secretion of gastrin and somatostatin from the rat stomach. Gastroenterology 1984; 86: 834–8.PubMedGoogle Scholar
  26. 24.
    Taborsky GJ: Evidence of a paracrine role for pancreatic somatostatin in vivo. Am J Physiol 1983; 245: E598–603.PubMedGoogle Scholar
  27. 25.
    Wass JAM, Penman E, Dryburgh JR, et al: Circulating somatostatin after food and glucose in man. Clin Endocrinol 1980; 12: 569–74.CrossRefGoogle Scholar
  28. 26.
    Penman E, Wass JAH, Medbak S, Morgan L, Lewis JM, Sesser GM, Rees LH: Response of circulating immunoreactive somatostatin to nutritional stimuli in normal subjects. Gastroenterology 1981; 81: 692–9.PubMedGoogle Scholar
  29. 27.
    Tsuda K, Sakurai H, Seino Y, Seino S, Tanigawa K, Kuzuya H, Imura H: Somatostatin-like immunoreactivity in human peripheral plasma measured by radioimmunoassay following affinity chromatography. Diabetes 1981; 30: 471–4.PubMedCrossRefGoogle Scholar
  30. 28.
    Zyznar ES, Pietri AO, Harris V, Unger RH: Evidence for the hormonal status of somatostatin in man. Diabetes 1981; 30: 883–6.PubMedCrossRefGoogle Scholar
  31. 29.
    Vinik AI, Levitt NS, Pimstone BL, Wagner L: Peripheral plasma somatostatin-like immunoreactive responses to insulin hypoglycemia and a mixed meal in healthy subjects and in noninsulin-dependent maturity-onset diabetics. J Clin Endocrinol Metab 1981; 52: 330–7.PubMedCrossRefGoogle Scholar
  32. 30.
    Colturi TJ, Unger RH, Feldman M: Role of circulating somatostatin in regulation of gastric acid secretion, gastrin release, and islet cell function. J Clin Invest 1984; 74: 417–23.PubMedCrossRefGoogle Scholar
  33. 31.
    Schusdziarra V, Lawecki J, Ditschuneit HH, Lukas B, Maier V, Pfeiffer EF: Effect of low-dose somatostatin infusion on pancreatic and gastric endocrine function in lean and obese nondiabetic human subjects. Diabetes 1985; 34: 595–601.PubMedCrossRefGoogle Scholar
  34. 32.
    Lucey MR, Wass JAM, Fairclough P, Webb J, Webb S, Medbak S, Rees LH: Autonomic regulation of postprandial plasma somatostatin, gastrin, and insulin. Gut 1985; 26: 683–8.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Werner Creutzfeldt
    • 1
  1. 1.Division of Gastroenterology and Metabolism, Department of MedicineUniversity of GottingenGermany

Personalised recommendations