Somatostatin pp 193-200 | Cite as

Cytoprotection by Somatostatins

  • K. H. Usadel
  • H. Kessler
  • G. Rohr
  • K. Kusterer
  • K. D. Palitzsch
  • U. Schwedes
Part of the Serono Symposia, USA book series (SERONOSYMP)


Several compounds, i.e., ethanol, acids, bases, histamine and others which are completely different in their chemical structures have the ability to injure gastric mucosa following oral administration in experimental animals and in humans (1). Histological changes include hemorrhagic lesions and necrosis of the epithelium.


Acute Pancreatitis Cytoprotective Effect Diphtheria Toxin Pancreatitis Associate Protein Gastric Cytoprotection 
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  1. 1.
    Robert A, Nezamis JE, Lancaster C, Hanchar AJ. Cytoprotection by prostaglandins in rats: prevention of gastric necrosis produced by alcohol, HCL, NaOH, hypertonic NaCL and thermal injury. Gastroenterology 1979; 77: 433.PubMedGoogle Scholar
  2. 2.
    Miller TA. Protective effects of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms. Am J Physiol 1983; 245: G601.PubMedGoogle Scholar
  3. 3.
    Robert A. Cytoprotection by prostaglandins. Gastroenterology 1979; 77: 761.PubMedGoogle Scholar
  4. 4.
    Lacy ER, Ito S. Microscopic analysis of ethanol damage to rat gastric mucosa after treatment with a prostaglandin. Gastroenterology 1982; 83: 619.PubMedGoogle Scholar
  5. 5.
    Szabo S, Trier JS, Frankel PW. Sulfhydryl compounds may mediate gastric cytoprotection. Science 1981; 214: 200.PubMedCrossRefGoogle Scholar
  6. 6.
    Schwedes U, Usadel KH, Szabo S. Cysteamine-induced duodenal ulcer: prevention by somatostatin (SRIF). Eur J Pharmacol 1975; 44: 195.CrossRefGoogle Scholar
  7. 7.
    Usadel KH, Schwedes U, Wdowinski JM. Pharmacol effects of somatostatin in acute organ lesion. Inn Med 1982; 9: 204.Google Scholar
  8. 8.
    Szabo S, Usadel KH. Cytoprotection-organoprotection by somatostatin: gastric and hepatic lesions. Experientia 1982; 38: 245.CrossRefGoogle Scholar
  9. 9.
    Usadel KH, Schwedes U, eds Proceedings of the international symposium: Mechanisms of cell injury, cytoprotection-organoprotection. Klin Wochenschr, 1986 (in press).Google Scholar
  10. 10.
    Reichlin S. Somatostatin. N Engl J Med 1983; 309:1495 and 1556.Google Scholar
  11. 11.
    Cicero GF, Laugier R, Sahel J, Manganaro M, Sarles H. Effects of somatostatin on clinical, biochemical and morphological changes following ERCP. Ital J Gastroenterol 1985; 17: 265.Google Scholar
  12. 12.
    Usadel RH, Uberla KR, Leuschner U. Treatment of acute pancreatitis with somatostatin: results of the multicenter double-blind trial (APTS-Study). Dig Dis Sci 1985; 30: 992.Google Scholar
  13. 13.
    Kayasseh L, Gyr K, Keller U, Stalder GA. Somatostatin and cimetidine in peptic-ulcer haemorrhage. Lancet 1980; I: 844.Google Scholar
  14. 14.
    Coraggio F, Scarpato P, Spina M, Lombardi S. Somatostatin and ranitidine in the control of iatrogenic haemorrhage of the upper gastrointestinal tract. Br Med J 1984; 289: 224.CrossRefGoogle Scholar
  15. 15.
    Magnusson I, Ihre T, Johansson C, Selingson U, Torngren S, UvnasMoberg K. Randomised double-blind trial of somatostatin in the treatment of massive upper gastrointestinal haemorrhage. Gut 1985; 26: 221.PubMedCrossRefGoogle Scholar
  16. 16.
    Antonioli A, Gandolfo M, Rigo GP, et al. Somatostatin and cimetidine in the control of acute upper gastrointestinal bleeding, a controlled multicenter study. Hepatogastroenterology 1986; 33: 71.PubMedGoogle Scholar
  17. 17.
    Bauer W, Briner U, Doepfner W, et al. SMS 201–995: a very potent and selective octapeptide analogue of somatostatin with prolonged action. Life Sci 1982; 31: 1133.PubMedCrossRefGoogle Scholar
  18. 18.
    Veber DF, Freidinger RM, Schwenk Perlow D, et al. A potent cycle hexapeptide analogue of somatostatin. Nature 1981; 292: 55.PubMedCrossRefGoogle Scholar
  19. 19.
    Lamberts SWJ, Oosterom R, Neufeld M, del Pozo E. The somatostatin analogue SMS 201–995 induces long-acting inhibition of growth hormone secretion without rebound hypersecretion in acromegalic patients. J Clin Endocrinol Metab 1985; 60: 1161.PubMedCrossRefGoogle Scholar
  20. 20.
    Plewe G, Schrezenmeir J, Nolken G, et al. Long-term treatment of acromegaly with the somatostatin analogue SMS 201–995 over 6 months. Klin Wochenschr 1986; 64: 389.PubMedCrossRefGoogle Scholar
  21. 21.
    Del Pozo E, Neufeld M, Schluter K, et al. Endocrine profile of a long-acting somatostatin derivative SMS 201–995, study in normal volunteers following subcutaneous administration. Acta Endocrinol (Copenh) 1986; 111: 433.Google Scholar
  22. 22.
    Ziegler K, Frimmer M, Kessler H, et al. Modified somatostatin as inhibitors of a multispecific transport system for bile acids and phallotoxins in isolated hepatocytes. Biochim Biophys Acta 1985; 845: 86.PubMedCrossRefGoogle Scholar
  23. 23.
    Kessler H, Bernd M, Damm I. Peptide confirmations, NMR investigations of cyclic hexapeptides containing the active sequence of somatostatin. Tetrahedron Letters 1982; 23: 4685.CrossRefGoogle Scholar
  24. 24.
    Kessler H, Eiermann V. Peptide confirmations, hormone and hetero-nuclear 2 D NMR spectroscopy of cyclic pentapeptides containing the active sequence of somatostatin. Tetrahedron Letters 1982; 23: 4689.CrossRefGoogle Scholar
  25. 25.
    Rao GS, Lemoch H, Kessler H, Damm I, Knoll S, Usadel KH. Cytoprotection by novel synthetic analogues of somatostatin. Acta Endocrinol (Copenh) 1984; 105 (suppl 264): 96.Google Scholar
  26. 26.
    Heimann ML, Nekola MV, Murphy WA, Lance VA, Coy DR. An extremely sensitive in vitro model for elucidating structure-activity relationships of growth hormone-releasing factor analogs. Endocrinology 1985; 116: 410.CrossRefGoogle Scholar
  27. 27.
    Keim V, Rohr G, Stockert HG, Haberich FJ. An additional secretory protein in the rat pancreas. Digestion 1984; 29: 242.PubMedCrossRefGoogle Scholar
  28. 28.
    Lankisch PG, Winckler K, Bohrmann M, Schmidt H, Creutzfeldt W. The influence of glucagon on acute experimental pancreatitis in the rat. Scand J Gastroenterol 1974; 9: 725.PubMedGoogle Scholar
  29. 29.
    Szabo S. Somatostatin stimulates clearance and hepatic uptake of colloidal carbon in the rat. Life Sci 1983; 3: 1975.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • K. H. Usadel
    • 1
  • H. Kessler
    • 2
  • G. Rohr
    • 1
  • K. Kusterer
    • 1
  • K. D. Palitzsch
    • 1
  • U. Schwedes
    • 1
  1. 1.II. Medizinische KlinikKlinikum Mannheim UniversityHeidelbergGermany
  2. 2.Institut fur Organische ChemieUniversity of FrankfurtGermany

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