Somatostatin pp 111-119 | Cite as

Mode of Action of Somatostatin in Islet B-Cells: Influence on Glucose-, L-Isoleucine- and Glyburide-Induced Electrical Activity

  • Caroline S. Pace
Part of the Serono Symposia, USA book series (SERONOSYMP)


The widespread role of somatostatin (SRIF, somatotropin release inhibiting factor) as a modulator of neural activity as well as endocrine and exocrine secretion has stimulated interest in its mechanism of action.


Islet Cell Pancreatic Islet Insulin Release Spike Activity Electrical Response 
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  1. 1.
    Pace CS. Somatostatin: control of stimulus-secretion coupling in pancreatic islet cells. In: Bloom FE, ed. Peptides: integrators of cell and tissue function. New York: Raven Press, 1980.Google Scholar
  2. 2.
    Pace CS, Tarvin JT. Somatostatin: mechanism of action in pancreatic islet B-cells. Diabetes 1981; 37: 836–42.CrossRefGoogle Scholar
  3. 3.
    Alberti KGMM, Christensen SE, Iversen J, et al. Inhibition of insulin secretion by somatostatin. Lancet 1973; 2: 1299–1301.PubMedCrossRefGoogle Scholar
  4. 4.
    Chideckel EW, Palmer J, Koerker DJ, Ensinck J, Davidson MB, Goodner CJ. Somatostatin blockade of acute and chronic stimuli of the endocrine pancreas and the consequences of this blockage on glucose homeostasis. J Clin Invest 1975; 55: 754–62.PubMedCrossRefGoogle Scholar
  5. 5.
    Efendic S, Luft R. Studies on the mechanism of somatostatin action on insulin release in man. I. Effect of blockade of a-adrenergic receptors. Acta Endocrinol (Copenh) 1975; 78: 516–23.Google Scholar
  6. 6.
    Efendic S, Luft R, Claro A. Studies on the mechanism of somatostatin action on insulin release in man. II. Comparison of the effects of somatostatin on insulin release induced by glucose, glucagon and tolbutamide. Acta Endocrinol (Copenh) 1976; 81: 743–52.Google Scholar
  7. 7.
    Gerich JE, Lorenzi M, Schneider V, Forsham PH. Effect of somatostatin on plasma glucose and insulin responses to glucagon and tolbutamide in man. J Clin Endocrinol Metab 1974; 39: 1057–60.PubMedCrossRefGoogle Scholar
  8. 8.
    Koerker DJ, Ruch W, Chideckel E, et al. Somatostatin: hypothalamic inhibitor of the endocrine pancreas. Science 1974; 184: 482–4.PubMedCrossRefGoogle Scholar
  9. 9.
    Leblanc H, Anderson JR, Sigel MB, Yen SSC. Inhibitory action of somatostatin on pancreatic a and B-cell function. J Clin Endocrinol Metab 1975; 40: 568–72.PubMedCrossRefGoogle Scholar
  10. 10.
    Iversen J, Hermansen K. Characterization of the inhibitory effect of somatostatin upon insulin and glucagon release in the isolated perfused canine pancreas: evidence for interaction with calcium. Metabolism 1980; 29: 151–60.PubMedCrossRefGoogle Scholar
  11. 11.
    Henquin JC86Meissner HP. Effects of amino acids on membrane potential and Rb fluxes in pancreatic B-cells. Am J Physiol 1981; 240:E245–52.Google Scholar
  12. 12.
    Henquin g, Meissner HP. Opposite effects of tolbutamide and diazoxide on Rb fluxes and membrane potential in pancreatic B-cells. Biochem Pharmacol 1982; 31: 1407–15.CrossRefGoogle Scholar
  13. 13.
    Gylfe E, Hellman B, Sehlin J, Taljedal I-B. Interaction of sulfonylurea with the pancreatic B-cell. Experientia 1984; 40: 1126–34.PubMedCrossRefGoogle Scholar
  14. 14.
    Boschero AC, Malaisse WJ. Stimulus-secretion coiling of glucose-induced insulin release. XXIX. Regulation of Rb efflux from perifused islets. Am J Physiol 1979; 236: E139–46.PubMedGoogle Scholar
  15. 15.
    Sehlin J, Taljedal I-B. Transport of rubidium and sodium in pancreatic islets. Am J Physiol 1979; 236: E139–46.Google Scholar
  16. 16.
    Nschero AC, Kawazu S, Duncan G, Malaisse WJ. Effect of glucose on K handling by pancreatic islets. FEBS Lett 1977; 83: 151–4.CrossRefGoogle Scholar
  17. 17.
    Henquin JC. D-Glucose inhibits potassium efflux from pancreatic islet cells. Nature 1978; 271: 271–3.PubMedCrossRefGoogle Scholar
  18. 18.
    Malaisse WJ, Boschero AC, Kawazu S, Hutton JC. The stimulus secretion couplin4 of glucose-induced insulin release. XXVII. Effect of glucose on K fluxes in isolated islets. Pflugers Arch 1978; 373: 237–42.PubMedCrossRefGoogle Scholar
  19. 19.
    Armstrong CM. Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons. J Gen Physiol 1971; 58: 4 1337.Google Scholar
  20. 20.
    Hille B. Ionic channels in nerve membranes. Prog Biophys Mol Biol (US) 1970; 21: 1–32.CrossRefGoogle Scholar
  21. 21.
    Stanfield PR. The effect of the tetraethylammonium ion on the delayed currents of frog skeletal muscle. J Physiol (Lond) 1970; 209: 209–29.Google Scholar
  22. 22.
    Henquin JC. Tetraethylammonium potentiation of insulin release and inhibition of rubidium efflux in pancreatic islets. Biochem Biophys Res Commun 1977; 77: 551–6.PubMedCrossRefGoogle Scholar
  23. 23.
    Atwater I, Ribalet B, Rojas E. Mouse pancreatic B-cells: tetraethylammonium blockage of the potassium permeability increase induced by depolarization. J Physiol (Lond) 1979; 288: 561–74.Google Scholar
  24. 24.
    Lew VL, Ferreira HG. Variable Ca sensitivity of a K-selective channel in intact red cell membranes. Nature 1976; 263: 336–8.PubMedCrossRefGoogle Scholar
  25. 25.
    Atwater I, Dawson CM, Ribalet B, Rojas E. Potassium permeability activated by intracellular calcium ion concentration in the pancreatic B-cell. J Physiol (Lond) 1979; 288: 575–88.Google Scholar
  26. 26.
    Henquin JC, Horemans B, Nenquin M, Verniers J, Lambert AE. Quinine induced modifications of insulin release and glucose metabolism by isolated pancreatic islets. FEBS Lett 1975; 57: 280–4.PubMedCrossRefGoogle Scholar
  27. 27.
    Oliver JR. Inhibition of calcium uptake by somatostatin in isolated rat islets of Langerhans. Endocrinology 1976; 99: 910–3.PubMedCrossRefGoogle Scholar
  28. 28.
    Bent-Hansen L, Capito K, Hedeskov CJ. The effect of calcium on somatostatin inhibition of insulin release and cyclic AMP production in mouse pancreatic islets. Biochem Biophys Acta 1979; 585: 240–9.PubMedCrossRefGoogle Scholar
  29. 29.
    Lin BJ. Effects of somatostatin on insulin biosynthesis, glucose oxidation, and cyclic guanosine monophosphate level. Metabolism 1978; 27 (suppl 1): 1295–8.PubMedCrossRefGoogle Scholar
  30. 30.
    Cook DR, Hales CN. Intracellular ATP directly blocks K+ channels in pancreatic B-cells. Nature 1984; 311:271–3Google Scholar
  31. 31.
    Rorsman P, Trube G. Glucose dependent K channels in pancreatic B-cells are regulated by intracellular ATP. Pflugers Arch 1985; 405:305–9Google Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Caroline S. Pace
    • 1
  1. 1.University of Alabama at BirminghamBirminghamUSA

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