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Ion Channels in T Lymphocytes

  • Chapter
Mechanisms of Lymphocyte Activation and Immune Regulation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 213))

Abstract

Ion channels, proteins that gate the flux of ions across the cell membrane, control an impressive array of physiological processes, including conduction of nerve impulses, synaptic transmission, hormone secretion, generation of the heart beat, initiation of muscle contraction, and transduction of sensory stimuli. To a large extent, this diversity of functions is a reflection of the diversity of ion channel types. Several distinct channel types have been characterized in neurons using a variety of electrophysiological techniques (Table 1; see also ref. 1). In the past several years, some of the same channel types have been observed in cells outside the nervous system, raising the possibility that ion channels may serve functions in electrically non-excitable tissues that are quite distinct from their electrical activities in the nervous system. In fact, a collection of direct and indirect observations suggests that ion channels similar to those found in nerve and muscle participate in the control of biological events associated with cellular proliferation and cytokine production that are crucial to the functioning of the immune system.

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Author information

Author notes

  1. Thomas E. DeCoursey

    Present address: Department of Physiology, Rush Medical College, Chicago, IL, 60612, USA

Authors and Affiliations

  1. Department of Physiology & Biophysics, University of California, Irvine, CA, 92717, USA

    Michael D. Cahalan, Richard S. Lewis & Jeffrey B. Sutro

  2. Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, CA, 92717, USA

    K. George Chandy & Sudhir Gupta

Authors
  1. Michael D. Cahalan
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  2. K. George Chandy
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  3. Thomas E. DeCoursey
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  4. Sudhir Gupta
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  5. Richard S. Lewis
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  6. Jeffrey B. Sutro
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Editor information

Editors and Affiliations

  1. University of California, Irvine, California, USA

    Sudhir Gupta

  2. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

    William E. Paul  & Anthony S. Fauci  & 

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© 1987 Plenum Press, New York

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Cahalan, M.D., Chandy, K.G., DeCoursey, T.E., Gupta, S., Lewis, R.S., Sutro, J.B. (1987). Ion Channels in T Lymphocytes. In: Gupta, S., Paul, W.E., Fauci, A.S. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation. Advances in Experimental Medicine and Biology, vol 213. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5323-2_9

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  • DOI: https://doi.org/10.1007/978-1-4684-5323-2_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5325-6

  • Online ISBN: 978-1-4684-5323-2

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