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Human T Lymphocyte Activation

  • Claudio Milanese
  • Robert F. Siliciano
  • Neil E. Richardson
  • Hsiu-Ching Chang
  • Andres Alcover
  • Ellis L. Reinherz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 213)

Summary

The T lymphocyte receptor for antigen and histocompatibility molecules is a molecular complex comprised of five polypeptide chains. Both the 49KD alpha and 43KD beta chains are immunoglobulin-like and thus contain variable domains responsible for ligand binding. In contrast, the 20–25KD T3 gamma, delta and epsilon chains are monomorphic structures presumably involved in transmembrane signalling. The alpha and beta subunits are disulfide bonded to each other and held in noncovalent association with the T3 chains. T3-Ti receptor crosslinking leads to conformational modification of a second T lineage specific molecule, termed the 50KD T11 structure and in turn, protein kinase C activation, elevation in intracytoplasmic free calcium and Na+/H+ antiport stimulation.

Keywords

Major Histocompatibility Complex Phorbol Ester Antigen Receptor Beta Subunit Clonal Proliferation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Claudio Milanese
    • 1
  • Robert F. Siliciano
    • 1
  • Neil E. Richardson
    • 1
  • Hsiu-Ching Chang
    • 1
  • Andres Alcover
    • 1
  • Ellis L. Reinherz
    • 1
  1. 1.Laboratory of Immunobiology, Dana-Farber Cancer Institute and Department of MedicineHarvard Medical SchoolBostonUSA

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