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Activation of Natural Killer (NK) Cells and Mechanism of Their Cytotoxic Effects

  • Ronald B. Herberman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 213)

Abstract

Natural killer (NK) cells are lymphoid cells with spontaneous activity against a wide variety of tumor cell lines and against primary or metastatic tumor cells (1–3). It is now possible to isolate highly enriched populations of NK cells and demonstrate that this cytotoxic activity is mediated predominantly, if not solely, by a small subpopulation of lymphocytes, morphologically identified as large granular lymphocytes (LGL). In addition, a large proportion of LGL have NK activity (3,4). NK activity has been found to be positively regulated by a variety of agents, with the interferons and interleukin 2 (IL-2) being identified as the principal cytokines mediating this stimulation of reactivity (5).

Keywords

Natural Killer Tumor Necrosis Factor Cytoplasmic Granule Human Peripheral Blood Lymphocyte Large Granular Lymphocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Ronald B. Herberman
    • 1
  1. 1.Pittsburgh Cancer Institute and Departments of Medicine and PathologyUniversity of PittsburghPittsburghUSA

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