Advertisement

Murine T-Cell Receptor Genes

  • M. M. Davis
  • N. R. J. Gascoigne
  • T. Lindsten
  • C. Goodnow
  • Y. Chien
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 213)

Abstract

The recent identification of the molecules which govern T cell specificity and the genes which encode them (as reviewed in references 1–4) has now provided a strong structural basis from which to study the phenomena of T-cell recognition and differentiation. Major issues which are now approachable include the precise nature of the T cell receptor-MHC-antigen interactions and the purposes and mechanics of thymic maturation. A third nagging question has to do with the role (or absence of a role) of the γ chain in any of the above processes. After a brief review of current molecular genetic data, we will discuss our approaches to some of these issues.

Keywords

Cell Receptor Gene Rearrange Immunoglobulin Heavy Chain Gene Immunoglobulin Supergene Family Rearrange Immunoglobulin Heavy Chain Thymic Maturation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    M. M. Davis, Y. Chien, N. R. J. Gascoigne, and S. M. Hedrick. A murine T cell receptor gene complex: Isolation, structure and rearrangement. Immunol. Rev. 81:235, (1984).CrossRefGoogle Scholar
  2. 2.
    L. Hood, M. Kronenberg, and T. Hunkapiller. T-cell antigen receptors and the immunoglobulin supergene family. Cell 40:225. (1985).CrossRefGoogle Scholar
  3. 3.
    M. M. Davis. Molecular genetics of the T-cell receptor beta chain. Ann. Rev. Immunol. 3:537, (1985).CrossRefGoogle Scholar
  4. 4.
    M. Kronenberg, G. Siu, L. E. Hood and N. Shastri. The molecular genetics of the T-cell antigen receptor and T-cell antigen recognition. Ann. Rev. Immunol., in press (1986).Google Scholar
  5. 5.
    A. C. Hayday, D. Diamond, G. Tanigawa, J. Heilig, V. Folsom, H. Saito, and S. Tonegawa. Unusual features of the organization and diversity of T-cell receptor alpha chain genes. Nature 316:828, (1985).ADSCrossRefGoogle Scholar
  6. 6.
    A. Winoto, S. Mjolsness, and L. Hood. Genomic organization of the genes encoding the mouse T-cell receptor alpha chain. Nature 316:832, (1985).ADSCrossRefGoogle Scholar
  7. 7.
    Y. Yoshikai, S. P. Clark, S. Taylor, Y. Sophn, B. Wilson, M. Minden, and T. W. Mak. Organization and sequences of the variable, joining and constant region the human T-cell receptor alpha chain. Nature 316:837, (1985).ADSCrossRefGoogle Scholar
  8. 8.
    Y. Chien, N. R. J. Gascoigne, J. Kavaler, N. E. Lee, and M. M. Davis. Somatic recombination in a murine T cell receptor gene. Nature 309:322, (1984).ADSCrossRefGoogle Scholar
  9. 9.
    G. D. Yancopoulos, T. K. Blackwell, H. Suh, L. Hood, and F. W. Alt. Introduced T cell receptor variable region gene segments recombine in pre-B cells: Evidence that B and T cells use a common recombinase. Cell 44:251, (1986).CrossRefGoogle Scholar
  10. 10.
    R. Baer, K-C Chen, S. D. Smith, and T. H. Rabbitts. Fusion of an immunoglobulin variable gene and a T cell receptor constant gene in the chromosome 14 inversion associated with T cell tumors. Cell 43:705, (1986).CrossRefGoogle Scholar
  11. 11.
    P. Patten, T. Yokota, J. Rothbard, Y. Chien, K. Arai, and M. M. Davis. Structure, expression and divergence of T cell receptor beta-chain variable regions. Nature 312:40, (1984).ADSCrossRefGoogle Scholar
  12. 12.
    D. M. Becker, P. Patten, Y. Chien, T. Yokota, Z. Eshhar,, M. Giedlin, N. R. G. Gascoigne, C. Goodnow, K. Arai, and M. M. Davis. Variability and repertoire size in T cell receptor Va and Vβ gene segments. Nature 317:430, (1985).ADSCrossRefGoogle Scholar
  13. 13.
    D. Rice, and D. Baltimore. Regulated expression of an immunoglobulin kappa gene introduced into a mouse lymphoid cell line. Proc. Natl. Acad. Sci. USA 79:7862, (1982).ADSCrossRefGoogle Scholar
  14. 14.
    V. T. Oi, S. L. Morrison, L. A. Herzenberg, and P. Berg. Immunoglobulin gene expression in transformed lymphoid cells. Proc. Natl. Acad. Sci. USA 80:825, (1983).ADSCrossRefGoogle Scholar
  15. 15.
    S. D. Gillies, S. L. Morrison, V. T. Oi, and S. Tonegawa. A tissue-specific transcription enhancer element is lecated in the major intron of a rearranged immunoglobulin heavy chain gene. Cell 33:717, (1983).CrossRefGoogle Scholar
  16. 16.
    M. S. Neuberger, G. T. Williams, and R. O. Fox. Recombinant antibodies possessing novel effector functions. Nature 312:604, (1984).ADSCrossRefGoogle Scholar
  17. 17.
    L. E. Samelson, R. N. Germain, and R. Schwartz. Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid. Proc. Natl. Acad. Sci. USA 80:6972, (1983).ADSCrossRefGoogle Scholar
  18. 18.
    T. H. Watts, A. A. Brian, J. W. Kappler, P. Marrack, and H. M. McConnell. Antigen presentation by supported planar membranes containing affinity-purified I-A . Proc. Natl. Acad. Sci. USA 81:7564, (1984).ADSCrossRefGoogle Scholar
  19. 19.
    R. M. Zinkernagel, G. N. Callahan, A. Althage, S. Cooper, P. A. Klein, and J. Klein. On the thymus in the differentiation of H-2 self-recognition by T cells: Evidence for dual recognition? J. Exp. Med. 147:882, (1978).CrossRefGoogle Scholar
  20. 20.
    M. Bevan, and P. J. Fink. The influence of thymus H-2 antigens on the specificity of maturing killer and helper cells. Immunol. Rev. 42:3, (1978).CrossRefGoogle Scholar
  21. 21.
    L. E. Samelson, T. Lindsten, B. J. Fowlkes, P. van den Elsen, C. Terhorst, M. M. Davis, R. N. Germain, and R. H. Schwartz. Expression of genes of the T-cell antigen receptor complex in precursor thymocytes. Nature 315:765, (1985).ADSCrossRefGoogle Scholar
  22. 22.
    D. C. Schwartz, and C. R. Cantor. Separation of yeast chromosome-sized DNMAs by pulsed field gradient gel electrophoresis. Cell 37:67, (1984).CrossRefGoogle Scholar
  23. 23.
    G. F. Carie, and M. V. Olson. Separation of chromosomal DNA molecules from yeast by orthogonal field alternation gel electrophoresis. Nucl. Acids Res. 12:5647, (1984).CrossRefGoogle Scholar
  24. 24.
    N. R. J. Gascoigne, C. Goodnow, K. Dudzik, L. Rourke, V. T. Oi, and M. M. Davis. Chimeric proteins produced by T cell receptor-immunoglobulin gene fusions. In Immune Regulation by Characterized Polypeptides, G Goldstein, J-F Bach, H Wigzel eds. Alan R Liss, New York (1986) in press.Google Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • M. M. Davis
    • 1
  • N. R. J. Gascoigne
    • 1
  • T. Lindsten
    • 1
  • C. Goodnow
    • 2
  • Y. Chien
    • 1
  1. 1.Department of Medical MicrobiologyStanford University School of MedicineStanfordUSA
  2. 2.Clinical Immunology CentreUniversity of SydneySydneyAustralia

Personalised recommendations