Murine T-Cell Receptor Genes

  • M. M. Davis
  • N. R. J. Gascoigne
  • T. Lindsten
  • C. Goodnow
  • Y. Chien
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 213)


The recent identification of the molecules which govern T cell specificity and the genes which encode them (as reviewed in references 1–4) has now provided a strong structural basis from which to study the phenomena of T-cell recognition and differentiation. Major issues which are now approachable include the precise nature of the T cell receptor-MHC-antigen interactions and the purposes and mechanics of thymic maturation. A third nagging question has to do with the role (or absence of a role) of the γ chain in any of the above processes. After a brief review of current molecular genetic data, we will discuss our approaches to some of these issues.


Cell Receptor Gene Rearrange Immunoglobulin Heavy Chain Gene Immunoglobulin Supergene Family Rearrange Immunoglobulin Heavy Chain Thymic Maturation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • M. M. Davis
    • 1
  • N. R. J. Gascoigne
    • 1
  • T. Lindsten
    • 1
  • C. Goodnow
    • 2
  • Y. Chien
    • 1
  1. 1.Department of Medical MicrobiologyStanford University School of MedicineStanfordUSA
  2. 2.Clinical Immunology CentreUniversity of SydneySydneyAustralia

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