Murine T-Cell Receptor Genes
The recent identification of the molecules which govern T cell specificity and the genes which encode them (as reviewed in references 1–4) has now provided a strong structural basis from which to study the phenomena of T-cell recognition and differentiation. Major issues which are now approachable include the precise nature of the T cell receptor-MHC-antigen interactions and the purposes and mechanics of thymic maturation. A third nagging question has to do with the role (or absence of a role) of the γ chain in any of the above processes. After a brief review of current molecular genetic data, we will discuss our approaches to some of these issues.
KeywordsCell Receptor Gene Rearrange Immunoglobulin Heavy Chain Gene Immunoglobulin Supergene Family Rearrange Immunoglobulin Heavy Chain Thymic Maturation
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