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Coupling of B Cell Surface Ig, Ia and BSF1 Receptors to Intracellular “Second Messengers”

  • J. C. Cambier
  • J. T. Ransom
  • L. K. Harris
  • K. M. Coggeshall
  • Z. Z. Chen
  • M. K. Newell
  • L. B. Justement
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 213)

Abstract

Accumulating evidence indicates that quiescent, murine B lymphocytes have the capacity to respond to multiple physiologic regulatory species. Virtually all small B cells express receptor immunoglobulin of two classes, IgM and IgD which confer responsiveness to antigen. They respond to thymus dependent antigens, and anti-immunoglobulin antibodies which act as antigen surrogates, as determined by an increase in the expression of cell surface Ia (1,2). Under appropriate conditions anti-immunoglobulin antibodies also induce B cell blastogenesis and proliferation (3,4). These mitogenic antibodies mimic the effects of highly polymeric thymus independent antigens generally termed TI type 1 antigens. It appears that the minimal signal generated by mlg crosslinking by TD antigen or anti-Ig antibodies is sufficient for induction of Ia expression. However, the basis by which TIl antigens and certain surrogate antibodies induce proliferation remains unclear. Recent evidence indicates that quiescent B cells also respond to the T cell lymphokine BSF1 resulting in increased expression of surface Ia (5–7). BSF1 also has a general viability promoting effect on quiescent B cells, while nonmitogenic anti-Ig antibodies adversely effect cell viability (J. Cambier, unpublished observations). Studies by Mond et al (8) and ourselves (unpublished observations) indicate that small B cells are responsive to interferony as well as αa and γ endorphins. Cloned IFNγ and endorphins inhibit anti-Ig induction of Ia expression and proliferation.

Keywords

Transmembrane Signaling Induce Membrane Depolarization Membrane Immunoglobulin Thymus Dependent Antigen Cell Permeant cAMP Analog 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • J. C. Cambier
    • 1
  • J. T. Ransom
    • 1
  • L. K. Harris
    • 1
  • K. M. Coggeshall
    • 1
  • Z. Z. Chen
    • 1
  • M. K. Newell
    • 1
  • L. B. Justement
    • 1
  1. 1.Division of Basic Immunology, Department of MedicineNational Jewish Center for Immunology and Respiratory MedicineDenverUSA

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