Transmembrane Signaling Reactions Generated in B Cells in Response to ANTI-IgM or Lipopolysaccharide

  • Anthony L. DeFranco
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 213)


The development and activation of B lymphocytes appear to be highly regulated by antigen or other agents interacting with mIgM and mIgD, products of helper T cells and macrophages, complement fragments, and bacterial products such as lipopolysaccharide (LPS) (1,2). One approach toward understanding this rich complexity is to define how the B cell translates these extracellular signals into intracellular biochemical reactions that may contribute to the regulation of growth and development of the cell. The recent work on signal transduction from membrane IgM and from the putative receptor for LPS are described.


Adenylate Cyclase Phosphatidic Acid Pertussis Toxin Calcium Ionophore Cytoplasmic Calcium 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Anthony L. DeFranco
    • 1
  1. 1.Department of Microbiology and Immunology and the G.W. Hooper FoundationUniversity of CaliforniaSan FranciscoUSA

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