Delineation of Human B Cell Differentiation: Immunological and Molecular Characterization of Human B Cell Differentiation Factor (BSF-2)

  • Tadamitsu Kishimoto
  • Toshio Hirano
  • Hitoshi Kikutani
  • Atsushi Muraguchi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 213)


B cells, which are responsible for the secretion of antibodies, originate from pluripotent hematopoietic stem cells and differentiation stages, such as pre-B cells, mature B cells, activated B cells and antibody secreting cells. The commitment of each B cell clone to a specific antigen occurs at the pre-B cell level and mature B cells express IgM molecules as antigen receptors on their surface. Binding of an antigen complementary to the receptors of a certain B cell clone initiates a complex series of the activation process resulting into antibody secreting cells. This process of clonal expansion and differentiation requires the collaboration of helper T cells. Recently, the T cell-dependent activation process of B cells into antibody secreting cells has been extensively studied and the involvement of B cell specific growth and differentiation factors in this process has been demonstrated (1,2). The results are schematically summarized in Fig. 1.


Culture Supernatant Phosphatidyl Inositol Partial Amino Acid Sequence Antibody Secreting Cell Cell Differentiation Factor 


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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Tadamitsu Kishimoto
    • 1
  • Toshio Hirano
    • 1
  • Hitoshi Kikutani
    • 1
  • Atsushi Muraguchi
    • 1
  1. 1.the Institute for Molecular and Cellular BiologyOsaka UniversityOsakaJapan

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