The Activation, Proliferation, and Differentiation of Human B Lymphocytes

  • Julian L. AmbrusJr.
  • Cynthia H. Jurgensen
  • Debra L. Bowen
  • Shohken Tomita
  • Toshimasa Nakagawa
  • Naoko Nakagawa
  • Harris Goldstein
  • Normal L. Witzel
  • Howard S. Mostowski
  • Anthony S. Fauci
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 213)


Efforts to evaluate normal human B cell physiology have resulted in the development of a model in which a resting B cell must progress through stages of activation, proliferation, and differentiation before becoming an immunoglobulin (Ig)-producing cell (1–4). Presumably each of these stages has specific signals, positive as well as negative, which control the nature as well as the intensity of the response. To evaluate the validity of this model, researchers have looked for reagents which act selectively at each of these stages. These include antigens, mitogens, soluble factors produced by various cell types, and various pharmacologic agents. In this review we will emphasize some of the studies performed in our laboratory on the various stages of B cell function in humans.


Murine System Lymphoma Line Solubilized Membrane Protein Cell Differentiation Factor Adenylate Cyclase Activator Forskolin 


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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Julian L. AmbrusJr.
    • 1
  • Cynthia H. Jurgensen
    • 1
  • Debra L. Bowen
    • 1
  • Shohken Tomita
    • 1
  • Toshimasa Nakagawa
    • 1
  • Naoko Nakagawa
    • 1
  • Harris Goldstein
    • 1
  • Normal L. Witzel
    • 1
  • Howard S. Mostowski
    • 1
  • Anthony S. Fauci
    • 1
  1. 1.Laboratory of Immunoregulation, National Institute of Allergy and Infectious DiseasesNational Institutes of Health BethesdaUSA

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