IL-2 Receptor Gene Activation by ATL-Derived Factor (ADF)

  • Junji Yodoi
  • Masafumi Okada
  • Yutaka Tagaya
  • Yoshihisa Taniguchi
  • Keisuke Teshigawara
  • Tadashi Kasahara
  • Charles A. Dinarello
  • Kohi Matsushima
  • Tasuku Honko
  • Takashi Uchiyama
  • Michiyuki Maeda
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 213)


The interaction of Interleukin 2 (IL-2) and its specific receptor, Interleukin 2 receptor (IL-2R) (1), plays an important role for the growth and activation of lymphoid cells. One of the unique features of lymphocytes in immune system is the selective proliferation of the clones specific for variety of the antigens. In mature T lymphocytes (T-cells) which express antigen-specific T-cell receptors, the cell growth driven by IL-2/IL-2-R interaction appears to be strictly regulated by the initiative signals elicited by the interaction between T-cell receptors and the corresponding antigens.


Phorbol Myristate Acetate Leukocytic Pyrogen Chest Disease Research Institute Crude Conditioned Medium 
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  1. 1.
    R. J. Robb, A. Munck and K. A. Smith. T cell growth factor receptors. Quantitation, specificity and biological relevance. J.Exp. Med. 154:1455, (1981).CrossRefGoogle Scholar
  2. 2.
    J. Yodoi, K. Takatsuki, and T. Masuda. Two cases of T-cell chronic lymphocytic leukemia in Japan. New Engl. J. Med. 290:572, (1974).Google Scholar
  3. 3.
    T. Uchiyama, J. Yodoi, K. Sagawa, K. Takiatsuki, and H. Uchion. Adult T cell leukemia. Clinical and hematologic features of sixteen cases. Blood 50:481, (1977).Google Scholar
  4. 4.
    T. Hattori, T. Uchiyama, T. Toibana, K. Takatsuki, and H. Uchino. Surface phenotype of Japanese adult T-cell leukemia cells characterized by monoclonal antibodies. Blood 58:645. (1981).Google Scholar
  5. 5.
    M. Tsudo, T. Uchiyama, H. Uchino, and J. Yodoi. Failure of regulation of Tac antigen/TCGF receptor on adult T cell leukemia cells by anti-Tac monoclonal antibody. Blood 61:1014. (1983).Google Scholar
  6. 6.
    M. Maeda, A. Shimizu, K. Ikuta, H. Okamoto, M. Kashihara, T. Uchiyama, T. Honjo, and J. Yodoi. Origin of HTLV-I(+) T-cell lines in adult T-cell leukemia: analysis on T-cell receptor gene rearrangement. J. Exp. Med, in press, (1985).Google Scholar
  7. 7.
    T. Uchiyama, T. Hori, M. Tsudo, Y. Wano, H. Umadome, S. Tamori, J. Yodoi, M. Maeda, H. Sawami, and H. Uchino. Interleukin-2 receptor (Tac antigen) expressed on adult T cell leukemia cells. J. Clinical Invest. 76:446, (1985).CrossRefGoogle Scholar
  8. 8.
    M. Tsudo, T. Uchiyama, K. Takatsuki, H. Uchino, and J. Yodoi. Modulation of Tac antigen on activated human T cells by anti-Tac monoclonal antibody. J. Immunol. 129:592, (1982).Google Scholar
  9. 9.
    T. Uchiyama, S. Broder, and T. A. Waldmann. A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells I. Production of anti-Tac monoclonal antibody and distribution of Tac(+) cells. J. Immunol. 126:1393, (1981).Google Scholar
  10. 10.
    W. J. Leonard, J. M. Depper, T. Uchiyama, K. A. Smith, T. A. Waldmann, and W. C. Greene. A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of receptor. Nature 300:267, (1982).ADSCrossRefGoogle Scholar
  11. 11.
    Y. Wano, T. Uchiyama, H. Uchino, M. Maeda, K. Fikui, and J. Yodoi. Characterization of human interleukin 2 receptor (Tac antigen) in normal and leukemic T cells: Co-expression of normal and aberrant receptors on Hut-102 cells. J. Immunol. 132:3005, (1984).Google Scholar
  12. 12.
    Y. Wano, T. Uchiyama, J. Yodoi, and H. Uchino. Biosynthetic processing of human interleukin-2 receptors (Tac antigen). Microbiol. Immunol. 29:451, (1985).Google Scholar
  13. 13.
    T. Nikaido, A. Shimizu, N. Ishida, H. Sabe, K. Teshigawara, M. Maeda, T. Uchiyama, J. Yodi, and T. Honjo. Molecular cloning of cDNA encoding human interleukin 2 receptor. Nature 311:631, (1984).ADSCrossRefGoogle Scholar
  14. 14.
    W. J. Leonard, J. M. Depper, G. R. Crabtree, S. Rudikoff, J. Pumphrey, R. J. Robb, M. Kronke, P. B. Svetlik, N. J. Peffer, T. A. Waldmann, and W. C. Greene, Molecular cloning and expression of cDNAs for the human interleukin-2 receptor: Evidence for alternate mRNA splicing and the use of two polyadenylatioii sites. Nature 311:626, (1984).ADSCrossRefGoogle Scholar
  15. 15.
    J. Yodoi, K. Teshigawara, T. Uchiyama, Y. Wano, M. Tsudo, T. Nikaido, K. A. Smith, and M. Maeda. Adult T-cell leukemia/lymphoma-derived factor augmenting TCGF (IL-2) receptor expression. In: Human T-cell leukemia-lymphoma viruses. R. C. Gallo, M. E. Essex, L. Gross, ed., Cold Spring Harbor Laboratory, New York, p255–259, (1984).Google Scholar
  16. 16.
    K. Teshigawara, M. Maeda, K. Nishino, T. Nikaido, T. Uchiyama, M. Tsudo, Y. Wano, and J. Yodoi. Adult T leukemia cells produce a lymphokine that augments interleukin. 2 receptor expression. J. Mol. Cell Immunol. 2:17, (1985).Google Scholar
  17. 17.
    J. Yodoi, K. Teshigawara, T. Nikaido, K. Fukui, T. Noma, T. Honjo, M. Takigawa, M. Sasaki, N. Minato, M. Tsudo, T. Uchiyama, and M. Maeda. TCGF(IL-2)-receptor inducing factor(s) I. Regulation of IL-2 receptor on a natural killer-like cell cell lines (YT cells). J. Immunol. 134:1623, (1985).Google Scholar
  18. 18.
    J. Yodoi, M. Maeda, Y. Wano, M. Tsudo, K. Teshigawara, and T. Uchiyama. TCGF(IL-2) receptor (Tac Ag) on ATL and non-ATL leukemia cells. In Thymic Hormones and Lymphokines 83’ (eds. A. L. Goldstein et al). Plenum Press, New York pp 273–277. (1984).CrossRefGoogle Scholar
  19. 19.
    M. Okada, M. Maeda, Y. Tagaya, T. Taniguchi, K. Teshigawara, T. Yoshiki, T. Diamantstein, K. A. Smith, T. Uchiyama, T. Honjo, and J. Yodoi. TCGF(IL-2)-receptor inducing factor(s). II. Possible role of ATL-derived factor (ADF) on constitutive IL-2 receptor expression of HTLV-I(+) T cell lines. J. Immunol. 135:3995, (1985).Google Scholar
  20. 20.
    K. Matsushima, M. Banno, W. R. Kidwell, and J. J. Oppenheim. Interleukin 1 increases collagen type IV production by murine mammary epithelial cells. J. Immunol. 134:904, (1983).Google Scholar
  21. 21.
    H. Osawa and T. Diamantstein. The characterization of a monoclonal antibody that binds specifically to rat T lymphocytes and inhibits IL-2 receptor functions. J. Immunol. 30:51, (1983).Google Scholar
  22. 22.
    L. J. Rosenwasser and C. A. Dinarello. Ability of human leukocyte pyrogen to enhance phytohemagglutinin induced murine thymocyte proliferation. Cell. Immunol. 63:134,(1981).CrossRefGoogle Scholar
  23. 23.
    Y. Yaoita and T. Honjo. Deletion of immunoglobulin heavy chain genes accompanies the class switch rearrangement. Biomed. Res. 1:164, (1980).Google Scholar
  24. 24.
    H. Aviv, and P. Leder. Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. 69:1408, (1972).Google Scholar
  25. 25.
    J. Yodoi, M. Okada, Y. Tagaya, K. Teshigawara, K. Fukui, M. Ishida, K. Ikuta, M. Maeda, T. Honjo, H. Osawa, T. Diamantstein, M. Tateno, and T. Yoshiki. Rat lymphoid cell lines with human T cell leukemia virus production. II. Constitutive expression of rat IL-2 receptor. J. Exp. Med. 164:924, (1985).CrossRefGoogle Scholar
  26. 26.
    S. Arya, F. Wong-Stall, and R. C. Gallo. T-cell growth factor gene. Lack of expression in human T-cell leukemia-lymphoma virus infected cells. Science 223:1086, (1984).ADSCrossRefGoogle Scholar
  27. 27.
    M. Hayami, A. Komuro, K. Nozawa, T. Shotake, K. Ihikawa, K. Yamamoto, T. Ishida, S. Honjo, and Y. Hinuma. Prevalence of anti-adult T cell leukemia virus (ATLV) antibody in Japanese monkeys and other non-human primates. Int. J. Cancer 33:179, (1984).CrossRefGoogle Scholar
  28. 28.
    N. Ishida, H. Kianamori, T. Noma, T. Nikiaido, H. Sabe, N. Suzuki, A. Shimizu, and T. Honjo. Molecular cloning and structure of the human interleukin 2 receptor gene. Nucl. Acad Res. 13:7579, (1985).CrossRefGoogle Scholar
  29. 29.
    W. J. Leonard, J. M. Depper, M. Kanehisa, Kronke, N. J. Petter, P. B. Svetlik, M. Sullivan, and W. C. Greene. Structure of the human interleukin-2 receptor gene. Science 230:633, (1985).ADSCrossRefGoogle Scholar
  30. 30.
    M. Seiki, S. Hattori, Y. Hirayama, and M. Yoshida. Human adult T-cell leukemia virus: Complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA. Proc. Natl. Acad. Sci. 80:3618, (1983).ADSCrossRefGoogle Scholar
  31. 31.
    W. A. Haseltine, J. Sodroski, R. Patarca, D. Briggs, D. Perkins, and F. Wong-Staal. Structure of 3’ terminal region of type II human T lymphotropic virus: evidence for new coding region. 225:419, (1984).Google Scholar
  32. 32.
    H. Sabe, A. Kondo, A. Shimizu, Y. Tagaya, J. Yodoi, H. Kobayashi, M. Hatanaka, N. Matsunami, M. Maeda, T. Noma, and T. Honjo. Properties of human interleukin-2 receptors expressed on non-lymphoid cells by cDNA transfection. Mol. Biol. Med. in press.Google Scholar
  33. 33.
    K. A. Smith, and D. A. Cantrell. Interleukin 2 regulates its own receptors. Proc. Natl. Acad. Sci. USA 82:864, (1985).ADSCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Junji Yodoi
    • 1
  • Masafumi Okada
    • 1
  • Yutaka Tagaya
    • 1
  • Yoshihisa Taniguchi
    • 1
  • Keisuke Teshigawara
    • 1
  • Tadashi Kasahara
    • 5
  • Charles A. Dinarello
    • 6
  • Kohi Matsushima
    • 7
  • Tasuku Honko
    • 2
  • Takashi Uchiyama
    • 4
  • Michiyuki Maeda
    • 3
  1. 1.Immunology Research InstiuteKyoto UniversityJapan
  2. 2.Department of Medical ChemistryKyoto UniversityJapan
  3. 3.Department of MedicineKyoto UniversityJapan
  4. 4.Faculty of Medicine, Chest Disease Research InstituteKyoto UniversityJapan
  5. 5.Jichi Medical SchoolJapan
  6. 6.New England Medical CenterUSA
  7. 7.National Cancer InstituteUSA

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