Autocrine Growth Function of Interleukin-1-Like Molecules Secreted by Neoplastic Human B Cells
Interleukin 1 (IL-1) molecules are hormone-like polypeptides that exert a variety of roles in immunoregulation and inflammation (1,2). The production of IL-1-like molecules, originally ascribed to monocyte cells (3), has been recently associated with normal non monocytic cell types such as human B cells and subsets of human large granular lymphocytes (4,5). The secretion of IL-1-like molecules in normal cells appears to be strictly regulated since it is dependent on specific stimuli such as lipopolysaccharide E. coli (LPS) or silica particles, and can be modulated by a variety of pharmacological agents or serum components (6). In recent years a variety of neoplastic cell types have been shown to constitutively secrete molecules whose biochemical and biological characteristics resemble those of monocyte-derived IL-1 (2).
KeywordsConditioned Medium Autocrine Growth Factor Mixed Leukocyte Reaction Mouse Thymocyte Autocrine Pathway
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- 4.J. J. Oppenehim, G. Scala, Y. d. Kuang, K. Matsushimma, M. B. Sztein, and P. S. Steeg. The role of cytokines in promoting accessory cell function. Progress in Immunology 5:285, (1984).Google Scholar
- 6.G. Scala, K. Matsushima, and J. J. Oppenheim. Inhibitory cells and factors that regulate the production and activities of interleukin 1 (IL-1). Proceedings of the International Symposium on Immunopharmacology. A. Miecher ed. Academic Press, (1984).Google Scholar
- 9.S. Venuta, R. Mertelsmann, K. Weite, S. P. Feldman, C. Y. Wang, and M. A. S. Moore. Production and regulation of interleukin-2 in human lymphoblastic leukemias studied with T-cell monoclonal antibodies. Blood 61:781, (1983).Google Scholar
- 10.S. Venuta, M. C. Turco, S. Feronne, L. Corbo, G. Morrone, K. Weite, and R. Mertelsmann. IL-2 and leukemia. In Oncogenes to Tumor Antigens G. Ciraldo et al. Elsevier Science Publishers pp 59, (1985).Google Scholar
- 15.G. Scala, G. Morrone, and S. Venuta. Autocrine growth function of Interleukin 1 -like molecules. Submitted.Google Scholar
- 18.M. M. Kelly, M. E. Rosemiller, A. J. Dauleno, and R. C. Newton. Development of an antibody specific for human interleukin 1. Lymphokine Res. 3:251, (1984).Google Scholar
- 21.C. H. Heldin, and B. Westermark. Growth factors: mechanism of action and relation to oncogenes. Cell 39, (1984).Google Scholar
- 22.M. Howard, S. B. Mizel, L. lachman, J. Ansel, B. Johnson, and W. E. Paul. Role of interleukin 1 in anti-immunoglobulin-induced B cell proliferation. J. Immunol. 135:1132, (1985).Google Scholar
- 23.K. Matsushima, A. Procopio, H. Abe, G. Scala, J. R. Ortaldo, and J. J. Oppenheim. Production of interleukin 1 activity by normal human peripheral blood B lymphocytes. J. Immunol. 135:1132. (1985).Google Scholar
- 25.A. Mantovani. Origin and function of tumor-associated macrophages in murine an human neoplasics. In Progress in Immunology V. T. Tada, Y. Yamamura eds. Academic Press, New York, pp 1001, (1984).Google Scholar
- 30.C. J. March, B. Mosley, A. Larsen, D. P. Cerretti, G. Braedt, V. Price, S. Gillis, C. S. Henney, S. R. Kronnheim, K. Grabstein, P. J. Conlon, T. P. Hopp. and D. Cosman. Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature 315:641, (1985).ADSCrossRefGoogle Scholar