The Multiple Biological Properties of Interleukin-1 Influencing Immunocompetent Cells

  • Charles A. Dinarello
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 213)


The acute phase response is a systemic, generalized reaction despite the fact that most disease processes which induce circulating IL-1 produced at the site of the disease, for example, the lung in pneumonia. Once released into the circulation, IL-1 acts on multiple target organs and induces a variety of biological changes. Considerable attention has also focused on the local production and activity of IL-1. Local concentrations of IL-1 in specialized tissues such as the skin, kidney, endothelium, lymph node and joint space may account for much of its role in disease processes. The role of IL-1’s in acute phase responses will be matched by interest in its effects on bone and cartilage destruction as well as the pathogenesis of arthrosclerosis. The ability of the various IL-1’s to activate lymphocytes, induce the synthesis of acute phase proteins, alter various metabolic and hematologic parameters and to produce fever and sleep has provided the evidence that IL-1’s are more than interleukins but rather multifunctional molecules capable of acting on different cells types.


Acute Phase Protein Acute Phase Response Human Vascular Endothelial Cell Multiple Biological Activity Endogenous Pyrogen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Plenum Press, New York 1987

Authors and Affiliations

  • Charles A. Dinarello
    • 1
  1. 1.From the Department of MedicineTufts University School of MedicineBostonUSA

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