The T Cell Receptor: Its Repertoire and Role in Thymocyte Development
Although the discovery of the genes and protein of the T cell receptor has solved some immunological problems many issues remain unsolved. These include questions of tolerance, the relationship between the structure and specificity of the T cell receptor and an understanding of the selective processes which occur in the thymus.
KeywordsCell Receptor Thymocyte Development Immature Thymocyte Human Thymocyte Thymus Lobe
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- 3.P. Marrack, S. Graham, J. Leibson, N. Roehm, D. Wegmann, and J. Kappler. Properties of antigen specific H-2 restricted T cell hybridomas. In: Isolation, Characterization and Utilization of T Lymphocyte Clones. Edited by F. Fitch and G. Fathman. Academic Press, New York, pp 119–126 (1982).Google Scholar
- 8.N. Roehm, A. Carbone, E. Kushnir, B. Taylor, R. Riblet, P. Marrack and J. Kappler. The major histocompatibility complex-restricted antigen receptor on T cells. VIII. The genetics of expression of an allotype. J. Immunol. 135:2176, (1985).Google Scholar
- 14.T. H. Mandel and M. M. Kennedy. The differentiation of murine thymocytes in vivo and in vitro. Immunology 35:317, (1978).Google Scholar
- 20.M. Bevan. In a radiation chimera host H-2 antigens determine the immune responsiveness of donor cytotoxic cells. Nature 269:417, (1977).Google Scholar
- 27.W. Born, M. McDuffie, N. Roehm, E. Kushnir, J. White, D. Thorpe, J. Stefano, J. Kappler and P. Marrack. Expression and role of the T cell receptor in early thymocyte differentiation in vitro. Submitted for publication.Google Scholar
- 29.M. McDuffie, W. Born, J. Kappler and P. Marrack. The role of the T cell receptor in thymocyte maturation: Effects of in vivo anti-receptor antibody. Proc. Nafl. Acad. Sci. (in press).Google Scholar