Pharmacological Control of 86Rb Efflux from Mouse Pancreatic Islets
Much attention has been paid to the K+ permeability of the plasma membrane in pancreatic β-cells because its control by physiological or pharmacological agents is an important step in the sequence of events leading to insulin release20. The existence of different K-channels in β-cells, first suggested on a pharmacological basis3,4,22, has been demonstrated recently by the patch clamp technique2,8,11. Elucidation of their respective physiological functions would be greatly facilitated by the availability of relatively specific inhibitors devoid of untoward effects in intact cells.
KeywordsIslet Cell Insulin Release Mouse Islet Mouse Pancreatic Islet Quinine Hydrochloride
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- 26.H.P. Meissner, Electrical characteristics of the beta cells in pancreatic islets, J. Physiol. (Paris) 72:757 (1976).Google Scholar