Pharmacological Control of 86Rb Efflux from Mouse Pancreatic Islets

  • J. C. Henquin
  • M. G. Garrino
  • M. Nenquin
  • G. Paolisso
  • M. Hermans
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 211)


Much attention has been paid to the K+ permeability of the plasma membrane in pancreatic β-cells because its control by physiological or pharmacological agents is an important step in the sequence of events leading to insulin release20. The existence of different K-channels in β-cells, first suggested on a pharmacological basis3,4,22, has been demonstrated recently by the patch clamp technique2,8,11. Elucidation of their respective physiological functions would be greatly facilitated by the availability of relatively specific inhibitors devoid of untoward effects in intact cells.


Islet Cell Insulin Release Mouse Islet Mouse Pancreatic Islet Quinine Hydrochloride 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • J. C. Henquin
    • 1
  • M. G. Garrino
    • 1
  • M. Nenquin
    • 1
  • G. Paolisso
    • 1
  • M. Hermans
    • 1
  1. 1.Unite de Diabetologie et Nutrition, Faculty of MedicineUniversity of LouvainBrusselsBelgium

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