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Biochemical Design Features of the Pancreatic Islet Cell Glucose-Sensory System

  • F. M. Matschinsky
  • M. Meglasson
  • A. Ghosh
  • M. Appel
  • F. Bedoya
  • M. Prentki
  • B. Corkey
  • T. Shimizu
  • D. Berner
  • H. Najafi
  • C. Manning
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 211)

Abstract

Our understanding of the biochemical basis of fuelstat function of the pancreatic islet cells is still fragmentary in contrast to the comprehensiveness of our knowledge about the morphology and physiology of pancreatic islets. The present account addresses several fundamental issues of β-cell biochemistry, namely the manner in which these cells keep track of the blood glucose level and how those blood glucose measurements might be coupled to insulin secretion. Expressed in the jargon of the field the presentation will deal with the pancreatic β-cell glucose-sensor-device and with the problem of stimulus-secretion-coupling.

Keywords

Insulin Secretion Pancreatic Islet Glucose Sensor Glucose Stimulate Insulin Secretion Glucose Induce Insulin Secretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • F. M. Matschinsky
    • 1
    • 2
  • M. Meglasson
    • 1
    • 2
  • A. Ghosh
    • 1
    • 2
  • M. Appel
    • 1
    • 2
  • F. Bedoya
    • 1
    • 2
  • M. Prentki
    • 1
    • 2
  • B. Corkey
    • 1
    • 2
  • T. Shimizu
    • 1
    • 2
  • D. Berner
    • 1
    • 2
  • H. Najafi
    • 1
    • 2
  • C. Manning
    • 1
    • 2
  1. 1.Diabetes Research Center and Department of Biochemistry and Biophysics, School of MedicineUniversity of PennsylvaniaWorcesterUSA
  2. 2.Department of Pathology, School of MedicineUniversity of MassachusettsWorcesterUSA

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