Role of Transglutaminase in Proinsulin Conversion and Insulin Release

  • R. Gomis
  • C. Alarcon
  • I. Valverde
  • W. J. Malaisse
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 211)


Among the biophysical events associated with insulin release, the translocation of secretory granules and their access to the exocytotic site are thought to be controlled by a microtubular-microfilamentous system. Only limited information is available on the enzymes involved in these mechanical events. This report deals with the possible role of transglutaminase in the secretory process.


Islet Cell Pancreatic Islet Insulin Release Secretory Granule Islet Function 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • R. Gomis
    • 1
  • C. Alarcon
    • 2
  • I. Valverde
  • W. J. Malaisse
    • 3
  1. 1.Diabetes Unit, Hormonal Laboratory, Hospital ClinicBarcelona UniversityBarcelonaSpain
  2. 2.Fundacion Jimenez DiazUniversidad Autonoma de MadridMadridSpain
  3. 3.Laboratory of Experimental MedicineBrussels Free UniversityBrusselsBelgium

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