Abstract
Among the biophysical events associated with insulin release, the translocation of secretory granules and their access to the exocytotic site are thought to be controlled by a microtubular-microfilamentous system. Only limited information is available on the enzymes involved in these mechanical events. This report deals with the possible role of transglutaminase in the secretory process.
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C. Alarcon, I. Valverde, and W.J. Malaisse, Transglutaminase and cellular motile events: retardation of proinsulin conversion by glycine methylester, Bioscience Reports 5:581 (1985).
P.J. Bungay, J.M. Potter, and M. Griffin, The inhibition of glucose-stimulated insulin secretion by primary amines. A role for transglutaminase in the secretory mechanism, Biochem. J. 219:819 (1984).
R. Gomis, M.A. Arbos, A. Sener, and W.J. Malaisse, Glucose-induced activation of transglutaminase in pancreatic islets, Diabetes Res. 3:115 (1986).
R. Gomis, M. Deleers, F. Malaisse-Lagae, A. Sener, P. Garcia-Morales, A. Rovira, I. Valverde, and W.J. Malaisse, Metabolic and secretory effects of methylamine in pancreatic islets, Cell. Biochem. Funct. 2:161 (1984).
R. Gomis, P.C.F. Mathias, P. Lebrun, F. Malaisse-Lagae, A. Sener, and W.J. Malaisse, Inhibition of translgutaminase by hypoglycaemic sulphonylureas in pancreatic islets and its possible relevance to insulin release, Res. Commun. Chem. Pathol. Pharmacol. 46:331 (1984).
R. Gomis, A. Sener, F. Malaisse-Lagae, and W.J. Malaisse, Transglutaminase activity in pancreatic islets, Biochim. Biophys. Acta 760:384 (1983).
R. Gomis, A. Sener, F. Malaisse-Lagae, and W.J. Malaisse, Corrigendum, Biochim. Biophys. Acta 757:141 (1983).
P. Lebrun, R. Gomis, M. Deleers, B. Billaudel, P.C.F. Mathias, A. Herchuelz, F. Malaisse-Lagae, A. Sener, and W.J. Malaisse, Methylamines and islet function: cationic aspects, J. Endocrinol. Invest. 7:345 (1984).
A. Sener, M.E. Dunlop, R. Gomis, P.C.F. Mathias, F. Malaisse-Lagae, and W.J. Malaisse, Role or transglutaminase in insulin release. Study with glycine and sarcosine methylesters, Endocrinology 117:237 (1985).
A. Sener, R. Gomis, B. Billaudel, and W.J. Malaisse, Facilitation of insulin release by N-p-tosylglycine, Biochem. Pharmacol. 34:2495 (1985).
A. Sener, R. Gomis, P. Lebrun, A. Herchuelz, F. Masaisse-Lagae, and W.J. Malaisse, Methylamine and islet function: possible relationship to Ca2+-sensitive transglutaminase, Mol. Cell. Endocrinol. 36:175 (1984).
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© 1986 Plenum Press, New York
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Gomis, R., Alarcon, C., Valverde, I., Malaisse, W.J. (1986). Role of Transglutaminase in Proinsulin Conversion and Insulin Release. In: Atwater, I., Rojas, E., Soria, B. (eds) Biophysics of the Pancreatic β-Cell. Advances in Experimental Medicine and Biology, vol 211. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5314-0_44
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DOI: https://doi.org/10.1007/978-1-4684-5314-0_44
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